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P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand

Overview of attention for article published in Journal of Neuroinflammation, July 2012
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Title
P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand
Published in
Journal of Neuroinflammation, July 2012
DOI 10.1186/1742-2094-9-172
Pubmed ID
Authors

Ying-mei Lu, Rong-rong Tao, Ji-yun Huang, Li-tao Li, Mei-hua Liao, Xiao-ming Li, Kohji Fukunaga, Ze-Hui Hong, Feng Han

Abstract

The cerebral microvascular occlusion elicits microvascular injury which mimics the different degrees of stroke severity observed in patients, but the mechanisms underlying these embolic injuries are far from understood. The Fas ligand (FasL)-Fas system has been implicated in a number of pathogenic states. Here, we examined the contribution of microglia-derived FasL to brain inflammatory injury, with a focus on the potential to suppress the FasL increase by inhibition of the P2X(7)-FasL signaling with pharmacological or genetic approaches during ischemia.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 28 97%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 5 17%
Student > Ph. D. Student 5 17%
Student > Master 4 14%
Student > Bachelor 3 10%
Student > Doctoral Student 2 7%
Other 3 10%
Unknown 7 24%
Readers by discipline Count As %
Medicine and Dentistry 7 24%
Agricultural and Biological Sciences 5 17%
Neuroscience 5 17%
Biochemistry, Genetics and Molecular Biology 3 10%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 7 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2016.
All research outputs
#18,317,537
of 22,681,577 outputs
Outputs from Journal of Neuroinflammation
#2,052
of 2,608 outputs
Outputs of similar age
#126,579
of 164,347 outputs
Outputs of similar age from Journal of Neuroinflammation
#49
of 64 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,608 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,347 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.