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Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease

Overview of attention for article published in BMC Systems Biology, October 2012
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2 X users

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Title
Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease
Published in
BMC Systems Biology, October 2012
DOI 10.1186/1752-0509-6-132
Pubmed ID
Authors

Isaac Crespo, Kirsten Roomp, Wiktor Jurkowski, Hiroaki Kitano, Antonio del Sol

Abstract

The activation of immune cells in the brain is believed to be one of the earliest events in prion disease development, where misfolded PrionSc protein deposits are thought to act as irritants leading to a series of events that culminate in neuronal cell dysfunction and death. The role of these events in prion disease though is still a matter of debate. To elucidate the mechanisms leading from abnormal protein deposition to neuronal injury, we have performed a detailed network analysis of genes differentially expressed in several mouse prion models.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Luxembourg 3 4%
United Kingdom 1 1%
Netherlands 1 1%
United States 1 1%
Spain 1 1%
Unknown 77 92%

Demographic breakdown

Readers by professional status Count As %
Researcher 23 27%
Student > Ph. D. Student 18 21%
Student > Bachelor 14 17%
Professor 6 7%
Other 6 7%
Other 14 17%
Unknown 3 4%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 35%
Biochemistry, Genetics and Molecular Biology 15 18%
Medicine and Dentistry 8 10%
Computer Science 7 8%
Engineering 6 7%
Other 12 14%
Unknown 7 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 September 2021.
All research outputs
#15,253,344
of 22,681,577 outputs
Outputs from BMC Systems Biology
#644
of 1,142 outputs
Outputs of similar age
#108,966
of 174,094 outputs
Outputs of similar age from BMC Systems Biology
#10
of 13 outputs
Altmetric has tracked 22,681,577 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,142 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,094 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.