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Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma

Overview of attention for article published in BMC Cancer, July 2016
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Title
Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma
Published in
BMC Cancer, July 2016
DOI 10.1186/s12885-016-2419-6
Pubmed ID
Authors

Jing-Jing Song, Si-Jia Zhao, Juan Fang, Da Ma, Xiang-Qi Liu, Xiao-Bing Chen, Yun Wang, Bin Cheng, Zhi Wang

Abstract

Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with clinicopathological parameters and prognosis in oral squamous cell carcinoma (OSCC). Foxp3 expression was examined using immunohistochemistry (IHC) in paraffin-embedded tissue samples from 273 OSCC patients. Statistical analysis was performed to evaluate the associations between Foxp3 expression, the clinicopathologic characteristics and prognostic factors in OSCC. Foxp3 protein expression was significantly associated with lymph node metastasis (P <0.01). Both univariate and multivariate analyses revealed that Foxp3 was an independent factor for both 5 years overall survival (OS) and relapse-free survival (RFS) (both P <0.01). Patients with Foxp3 overexpression had shorter OS and RFS. Our results determined that elevated Foxp3 protein expression was a predictive factor of outcome in OSCC and could act as a promising therapeutic target.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Other 2 18%
Student > Ph. D. Student 2 18%
Student > Master 2 18%
Researcher 1 9%
Professor > Associate Professor 1 9%
Other 1 9%
Unknown 2 18%
Readers by discipline Count As %
Medicine and Dentistry 4 36%
Agricultural and Biological Sciences 1 9%
Immunology and Microbiology 1 9%
Biochemistry, Genetics and Molecular Biology 1 9%
Unknown 4 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 July 2016.
All research outputs
#7,043,907
of 8,133,552 outputs
Outputs from BMC Cancer
#2,804
of 3,451 outputs
Outputs of similar age
#217,830
of 257,633 outputs
Outputs of similar age from BMC Cancer
#179
of 245 outputs
Altmetric has tracked 8,133,552 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,451 research outputs from this source. They receive a mean Attention Score of 3.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 245 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.