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Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases

Overview of attention for article published in BMC Cancer, July 2016
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Title
Transcriptome analysis of paired primary colorectal carcinoma and liver metastases reveals fusion transcripts and similar gene expression profiles in primary carcinoma and liver metastases
Published in
BMC Cancer, July 2016
DOI 10.1186/s12885-016-2596-3
Pubmed ID
Authors

Ja-Rang Lee, Chae Hwa Kwon, Yuri Choi, Hye Ji Park, Hyun Sung Kim, Hong-Jae Jo, Nahmgun Oh, Do Youn Park

Abstract

Despite the clinical significance of liver metastases, the difference between molecular and cellular changes in primary colorectal cancers (CRC) and matched liver metastases is poorly understood. In order to compare gene expression patterns and identify fusion genes in these two types of tumors, we performed high-throughput transcriptome sequencing of five sets of quadruple-matched tissues (primary CRC, liver metastases, normal colon, and liver). The gene expression patterns in normal colon and liver were successfully distinguished from those in CRCs; however, RNA sequencing revealed that the gene expression between primary CRCs and their matched liver metastases is highly similar. We identified 1895 genes that were differentially expressed in the primary carcinoma and liver metastases, than that in the normal colon tissues. A major proportion of the transcripts, identified by gene expression profiling as significantly enriched in the primary carcinoma and metastases, belonged to gene ontology categories involved in the cell cycle, mitosis, and cell division. Furthermore, we identified gene fusion events in primary carcinoma and metastases, and the fusion transcripts were experimentally confirmed. Among these, a chimeric transcript resulting from the fusion of RNF43 and SUPT4H1 was found to occur frequently in primary colorectal carcinoma. In addition, knockdown of the expression of this RNF43-SUPT4H1 chimeric transcript was found to have a growth-inhibitory effect in colorectal cancer cells. The present study reports a high concordance of gene expression in the primary carcinoma and liver metastases, and reveals potential new targets, such as fusion genes, against primary and metastatic colorectal carcinoma.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Researcher 8 17%
Student > Master 7 15%
Student > Bachelor 4 9%
Student > Doctoral Student 3 7%
Other 5 11%
Unknown 10 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 33%
Agricultural and Biological Sciences 8 17%
Immunology and Microbiology 5 11%
Medicine and Dentistry 4 9%
Mathematics 1 2%
Other 0 0%
Unknown 13 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2016.
All research outputs
#10,647,130
of 16,638,522 outputs
Outputs from BMC Cancer
#2,933
of 6,075 outputs
Outputs of similar age
#150,646
of 267,420 outputs
Outputs of similar age from BMC Cancer
#1
of 1 outputs
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So far Altmetric has tracked 6,075 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
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