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Medical bioremediation of age-related diseases

Overview of attention for article published in Microbial Cell Factories, April 2009
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50 Mendeley
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Title
Medical bioremediation of age-related diseases
Published in
Microbial Cell Factories, April 2009
DOI 10.1186/1475-2859-8-21
Pubmed ID
Authors

Jacques M Mathieu, John Schloendorn, Bruce E Rittmann, Pedro JJ Alvarez

Abstract

Catabolic insufficiency in humans leads to the gradual accumulation of a number of pathogenic compounds associated with age-related diseases, including atherosclerosis, Alzheimer's disease, and macular degeneration. Removal of these compounds is a widely researched therapeutic option, but the use of antibodies and endogenous human enzymes has failed to produce effective treatments, and may pose risks to cellular homeostasis. Another alternative is "medical bioremediation," the use of microbial enzymes to augment missing catabolic functions. The microbial genetic diversity in most natural environments provides a resource that can be mined for enzymes capable of degrading just about any energy-rich organic compound. This review discusses targets for biodegradation, the identification of candidate microbial enzymes, and enzyme-delivery methods.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 4%
Japan 1 2%
Uruguay 1 2%
Brazil 1 2%
Unknown 45 90%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 18%
Student > Ph. D. Student 8 16%
Researcher 7 14%
Student > Bachelor 5 10%
Professor 4 8%
Other 9 18%
Unknown 8 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 48%
Medicine and Dentistry 8 16%
Biochemistry, Genetics and Molecular Biology 4 8%
Engineering 2 4%
Chemistry 2 4%
Other 3 6%
Unknown 7 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2017.
All research outputs
#20,656,820
of 25,374,917 outputs
Outputs from Microbial Cell Factories
#1,401
of 1,823 outputs
Outputs of similar age
#99,181
of 107,456 outputs
Outputs of similar age from Microbial Cell Factories
#8
of 8 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,823 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 107,456 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one.