↓ Skip to main content

Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, July 2016
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

twitter
3 tweeters

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
34 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol
Published in
Journal of Experimental & Clinical Cancer Research, July 2016
DOI 10.1186/s13046-016-0398-8
Pubmed ID
Authors

Maria Pia Fuggetta, Valentina Bordignon, Andrea Cottarelli, Beatrice Macchi, Caterina Frezza, Paola Cordiali-Fei, Fabrizio Ensoli, Stefania Ciafrè, Francesca Marino-Merlo, Antonio Mastino, Giampietro Ravagnan

Abstract

Human T-cell leukemia virus (HTLV-1) is a lymphotropic retrovirus associated to adult T cell leukemia (ATL) and to non-neoplastic inflammatory conditions affecting the central nervous system, lung or skin. The inflammatory disorders associated to HTLV-1 are mediated by different proinflammatory cytokines as IL-1α, IL-6, TNF-α. The release and the role of IL-17 is still debated. Aims of this study were to analyze IL-17 induction by HTLV-1 infection and to determine whether resveratrol (RES) is able to down regulate the pathway of cytokines production either in HTLV-1 chronically infected MT-2 cell line or in human CD4+ cells infected in vitro with HTLV-1. MT-2 and HTLV-1 infected CD4+ cells were analyzed for proinflammatory cytokine production before or after RES treatment. The concentrations of IL-17, IL-1α, IL-6, and TNF-α were measured in cell culture supernatants by ELISA and SearchLight™ technology. The IL-17 mRNA expression was evaluated by RT-PCR. NF-kB activation was detected by non-radioactive, Electro Mobility Shift Assay (EMSA). HTLV-1 RNA expression was detected by Real-time-PCR (RQ-PCR). We found that RES is capable of inducing a dose-dependent inhibition of IL-1α, IL-6 and TNF-α production in vitro and can down regulate the expression of IL-17 at both mRNA and protein levels in HTLV-1 infected cells. This effect was associated with a dose-dependent inhibition of the of the nuclear factor kappa-B (NF-kB) activity. Conversely, RES did not apparently affect HTLV-1 proliferation. These results support the anti-inflammatory properties of RES, suggesting that it might be a useful therapeutic agent for the treatment of HTLV-1 related inflammatory diseases.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 3%
Unknown 33 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 21%
Researcher 6 18%
Student > Master 4 12%
Student > Doctoral Student 3 9%
Student > Ph. D. Student 3 9%
Other 5 15%
Unknown 6 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 10 29%
Agricultural and Biological Sciences 3 9%
Nursing and Health Professions 3 9%
Medicine and Dentistry 2 6%
Neuroscience 2 6%
Other 8 24%
Unknown 6 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2017.
All research outputs
#7,090,716
of 12,330,736 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#212
of 724 outputs
Outputs of similar age
#124,798
of 266,909 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#4
of 26 outputs
Altmetric has tracked 12,330,736 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 724 research outputs from this source. They receive a mean Attention Score of 2.4. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,909 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.