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Mendeley readers
| Title |
Electrospray tandem mass spectrometric analysis of a dimeric conjugate, salvialeriafone and related compounds
|
|---|---|
| Published in |
BMC Chemistry, October 2012
|
| DOI | 10.1186/1752-153x-6-120 |
| Pubmed ID | |
| Authors |
Syed Ghulam Musharraf, Madiha Goher, Amjad Hussain, M Iqbal Choudhary |
| Abstract |
Electrospray tandem mass spectrometry approach is widely used for the rapid characterization of natural products. This paper describes the gas-phased ESI-MS/MS fragmentation of abietane-type diterpenoids and their novel dimeric conjugate, salvialeriafone (1) using both positive and negative ion electrospray ionization quadropole time-of-flight mass spectrometry (ESI-QqTOF-MS/MS) hybrid instrument. Diterpenoids are widely distributed throughout the plant kingdom and posses interesting biological activities. ESI-QqTOF-MS (positive ion mode) of diterpenoids 1-6 under collision-induced dissociation tandem mass spectrometric analysis (CID-MS/MS) showed the characteristic losses of water, carbonmonoxide and propene molecules, while analysis in negative ion mode showed the characteristic losses of water, carbon monoxide, methane molecules and methyl radical. Results demonstrated the differences in the product ions and base peaks due to the differences in the skeleton. A novel dimeric conjugate, salvialeriafone (1) showed characteristic fragmentation pattern and was found to be more prone to form radical ions, as compared to monomeric diterpenoids. The fragmentation pathways of characteristic fragments were proposed with the aid of HRESIMS. Extensive tandem mass spectrometric studies of salvialeriafone (1) and related diterpenoids 2-6 were conducted and their characteristic fragments were identified. The knowledge of the fragmentation pattern of these diterpenoids will be useful for the characterization of new dimers of this class of compounds. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 2 | 20% |
| Student > Master | 2 | 20% |
| Lecturer | 1 | 10% |
| Student > Ph. D. Student | 1 | 10% |
| Student > Bachelor | 1 | 10% |
| Other | 2 | 20% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 30% |
| Agricultural and Biological Sciences | 2 | 20% |
| Chemical Engineering | 1 | 10% |
| Immunology and Microbiology | 1 | 10% |
| Social Sciences | 1 | 10% |
| Other | 1 | 10% |
| Unknown | 1 | 10% |