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Electrospray tandem mass spectrometric analysis of a dimeric conjugate, salvialeriafone and related compounds

Overview of attention for article published in Chemistry Central Journal, October 2012
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Title
Electrospray tandem mass spectrometric analysis of a dimeric conjugate, salvialeriafone and related compounds
Published in
Chemistry Central Journal, October 2012
DOI 10.1186/1752-153x-6-120
Pubmed ID
Authors

Syed Ghulam Musharraf, Madiha Goher, Amjad Hussain, M Iqbal Choudhary

Abstract

Electrospray tandem mass spectrometry approach is widely used for the rapid characterization of natural products. This paper describes the gas-phased ESI-MS/MS fragmentation of abietane-type diterpenoids and their novel dimeric conjugate, salvialeriafone (1) using both positive and negative ion electrospray ionization quadropole time-of-flight mass spectrometry (ESI-QqTOF-MS/MS) hybrid instrument. Diterpenoids are widely distributed throughout the plant kingdom and posses interesting biological activities. ESI-QqTOF-MS (positive ion mode) of diterpenoids 1-6 under collision-induced dissociation tandem mass spectrometric analysis (CID-MS/MS) showed the characteristic losses of water, carbonmonoxide and propene molecules, while analysis in negative ion mode showed the characteristic losses of water, carbon monoxide, methane molecules and methyl radical. Results demonstrated the differences in the product ions and base peaks due to the differences in the skeleton. A novel dimeric conjugate, salvialeriafone (1) showed characteristic fragmentation pattern and was found to be more prone to form radical ions, as compared to monomeric diterpenoids. The fragmentation pathways of characteristic fragments were proposed with the aid of HRESIMS. Extensive tandem mass spectrometric studies of salvialeriafone (1) and related diterpenoids 2-6 were conducted and their characteristic fragments were identified. The knowledge of the fragmentation pattern of these diterpenoids will be useful for the characterization of new dimers of this class of compounds.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Other 1 14%
Lecturer 1 14%
Student > Bachelor 1 14%
Student > Ph. D. Student 1 14%
Student > Master 1 14%
Other 1 14%
Unknown 1 14%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 2 29%
Agricultural and Biological Sciences 2 29%
Social Sciences 1 14%
Chemistry 1 14%
Unknown 1 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2012.
All research outputs
#3,175,923
of 4,504,869 outputs
Outputs from Chemistry Central Journal
#197
of 468 outputs
Outputs of similar age
#54,745
of 81,957 outputs
Outputs of similar age from Chemistry Central Journal
#1
of 3 outputs
Altmetric has tracked 4,504,869 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 468 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
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