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Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Overview of attention for article published in Biological Research, July 2016
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Title
Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence
Published in
Biological Research, July 2016
DOI 10.1186/s40659-016-0095-2
Pubmed ID
Authors

Shiva Marthandan, Uwe Menzel, Steffen Priebe, Marco Groth, Reinhard Guthke, Matthias Platzer, Peter Hemmerich, Christoph Kaether, Stephan Diekmann

Abstract

Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not successfully repaired, can result in senescence induction. Recently, we determined the transcriptional changes combined with the transition into replicative senescence in primary human fibroblast strains. Here, by γ-irradiation we induced premature cellular senescence in the fibroblast cell strains (HFF and MRC-5) and determined the corresponding transcriptional changes by high-throughput RNA sequencing. Comparing the transcriptomes, we found a high degree of similarity in differential gene expression in replicative as well as in irradiation induced senescence for both cell strains suggesting, in each cell strain, a common cellular response to error accumulation. On the functional pathway level, "Cell cycle" was the only pathway commonly down-regulated in replicative and irradiation-induced senescence in both fibroblast strains, confirming the tight link between DNA repair and cell cycle regulation. However, "DNA repair" and "replication" pathways were down-regulated more strongly in fibroblasts undergoing replicative exhaustion. We also retrieved genes and pathways in each of the cell strains specific for irradiation induced senescence. We found the pathways associated with "DNA repair" and "replication" less stringently regulated in irradiation induced compared to replicative senescence. The strong regulation of these pathways in replicative senescence highlights the importance of replication errors for its induction.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 28%
Student > Master 8 16%
Researcher 7 14%
Student > Bachelor 7 14%
Other 3 6%
Other 5 10%
Unknown 6 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 34%
Agricultural and Biological Sciences 9 18%
Medicine and Dentistry 6 12%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Nursing and Health Professions 1 2%
Other 5 10%
Unknown 10 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 April 2017.
All research outputs
#5,467,340
of 9,689,121 outputs
Outputs from Biological Research
#136
of 254 outputs
Outputs of similar age
#145,175
of 264,797 outputs
Outputs of similar age from Biological Research
#6
of 8 outputs
Altmetric has tracked 9,689,121 research outputs across all sources so far. This one is in the 26th percentile – i.e., 26% of other outputs scored the same or lower than it.
So far Altmetric has tracked 254 research outputs from this source. They receive a mean Attention Score of 2.8. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,797 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.