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The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial

Overview of attention for article published in Nutrition Journal, October 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

news
1 news outlet
blogs
3 blogs
twitter
30 tweeters
facebook
8 Facebook pages
googleplus
1 Google+ user
video
2 video uploaders

Citations

dimensions_citation
32 Dimensions

Readers on

mendeley
92 Mendeley
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Title
The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial
Published in
Nutrition Journal, October 2012
DOI 10.1186/1475-2891-11-86
Pubmed ID
Authors

Nicole M Wedick, Christos S Mantzoros, Eric L Ding, Aoife M Brennan, Bernard Rosner, Eric B Rimm, Frank B Hu, Rob M van Dam

Abstract

Findings from observational studies suggest that sex hormone-binding globulin (SHBG) and endogenous sex hormones may be mediators of the putative relation between coffee consumption and lower risk of type 2 diabetes. The objective of this study was to evaluate the effects of caffeinated and decaffeinated coffee on SHBG and sex hormone levels. After a two-week run-in phase with caffeine abstention, we conducted an 8-week parallel-arm randomized controlled trial. Healthy adults (n = 42) were recruited from the Boston community who were regular coffee consumers, nonsmokers, and overweight. Participants were randomized to five 6-ounce cups of caffeinated or decaffeinated instant coffee or water (control group) per day consumed with each meal, mid-morning, and mid-afternoon. The main outcome measures were SHBG and sex hormones [i.e., testosterone, estradiol, dehydroepiandrosterone sulfate]. No significant differences were found between treatment groups for any of the studied outcomes at week 8. At 4 weeks, decaffeinated coffee was associated with a borderline significant increase in SHBG in women, but not in men. At week 4, we also observed several differences in hormone concentrations between the treatment groups. Among men, consumption of caffeinated coffee increased total testosterone and decreased total and free estradiol. Among women, decaffeinated coffee decreased total and free testosterone and caffeinated coffee decreased total testosterone. Our data do not indicate a consistent effect of caffeinated coffee consumption on SHBG in men or women, however results should be interpreted with caution given the small sample size. This is the first randomized trial investigating the effects of caffeinated and decaffeinated coffee on SHBG and sex hormones and our findings necessitate further examination in a larger intervention trial.

Twitter Demographics

The data shown below were collected from the profiles of 30 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
Denmark 1 1%
Canada 1 1%
Unknown 88 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 21 23%
Researcher 8 9%
Student > Master 7 8%
Student > Ph. D. Student 6 7%
Student > Postgraduate 6 7%
Other 25 27%
Unknown 19 21%
Readers by discipline Count As %
Medicine and Dentistry 30 33%
Nursing and Health Professions 12 13%
Agricultural and Biological Sciences 10 11%
Biochemistry, Genetics and Molecular Biology 5 5%
Sports and Recreations 5 5%
Other 10 11%
Unknown 20 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 56. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2022.
All research outputs
#598,105
of 21,823,161 outputs
Outputs from Nutrition Journal
#178
of 1,404 outputs
Outputs of similar age
#3,393
of 171,100 outputs
Outputs of similar age from Nutrition Journal
#20
of 106 outputs
Altmetric has tracked 21,823,161 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,404 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 34.4. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,100 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.