The debate about whether Sirt1 is a principal longevity gene seems to ignore that most of us have a lifestyle and physical environments that are accelerating aging related diseases. https://t.co/LDVwVjjcqA
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Interaction of Sirtuin 1 (SIRT1) candidate longevity gene and particulate matter (PM2.5) on all-cause mortality: a longitudinal cohort study in China https://t.co/4NtRTm32Id
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SIRT1 vs PM2.5 pollution vs mortality (n=7,083) — Mortality for each 10 μg/m3 increase in PM2.5 HR=1.08 (1.05–1.11) — Two SIRT1_391 minor alleles vs zero (each 10 μg/m3 increase in PM2.5) HR=1.32 vs HR=1.06 — No significance SIRT1_366, SIRT1_773, SIRT1_720
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Can sirtuins, the longevity gene, protect the body against air pollution? See our cohort study finding in Environmental Health (published on Pi Day). https://t.co/MhkTUuQbIK #LONGEVITY #Genetics #Lifespan @BioMedCentral #Epidemiology #aging