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Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy

Overview of attention for article published in Orphanet Journal of Rare Diseases, July 2016
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Title
Altered skeletal muscle (mitochondrial) properties in patients with mitochondrial DNA single deletion myopathy
Published in
Orphanet Journal of Rare Diseases, July 2016
DOI 10.1186/s13023-016-0488-x
Pubmed ID
Authors

Saskia Maria Gehrig, Violeta Mihaylova, Sebastian Frese, Sandro Manuel Mueller, Maria Ligon-Auer, Christina M. Spengler, Jens A. Petersen, Carsten Lundby, Hans H. Jung

Abstract

Mitochondrial myopathy severely affects skeletal muscle structure and function resulting in defective oxidative phosphorylation. However, the major pathomechanisms and therewith effective treatment approaches remain elusive. Therefore, the aim of the present study was to investigate disease-related impairments in skeletal muscle properties in patients with mitochondrial myopathy. Accordingly, skeletal muscle biopsies were obtained from six patients with moleculargenetically diagnosed mitochondrial myopathy (one male and five females, 53 ± 9 years) and eight age- and gender-matched healthy controls (two males and six females, 58 ± 14 years) to determine mitochondrial respiratory capacity of complex I-V, mitochondrial volume density and fiber type distribution. Mitochondrial volume density (4.0 ± 0.5 vs. 5.1 ± 0.8 %) as well as respiratory capacity of complex I-V were lower (P < 0.05) in mitochondrial myopathy and associated with a higher (P < 0.001) proportion of type II fibers (65.2 ± 3.6 vs. 44.3 ± 5.9 %). Additionally, mitochondrial volume density and maximal oxidative phosphorylation capacity correlated positively (P < 0.05) to peak oxygen uptake. Mitochondrial myopathy leads to impaired mitochondrial quantity and quality and a shift towards a more glycolytic skeletal muscle phenotype.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 37 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 18%
Student > Doctoral Student 5 13%
Student > Bachelor 4 11%
Other 3 8%
Researcher 3 8%
Other 4 11%
Unknown 12 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 13%
Medicine and Dentistry 5 13%
Nursing and Health Professions 3 8%
Agricultural and Biological Sciences 2 5%
Sports and Recreations 2 5%
Other 6 16%
Unknown 15 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2016.
All research outputs
#18,466,751
of 22,881,964 outputs
Outputs from Orphanet Journal of Rare Diseases
#2,148
of 2,628 outputs
Outputs of similar age
#282,196
of 365,421 outputs
Outputs of similar age from Orphanet Journal of Rare Diseases
#28
of 30 outputs
Altmetric has tracked 22,881,964 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,628 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 6th percentile – i.e., 6% of its peers scored the same or lower than it.
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We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.