Title |
Effects of curcumin on stem-like cells in human esophageal squamous carcinoma cell lines
|
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Published in |
BMC Complementary Medicine and Therapies, October 2012
|
DOI | 10.1186/1472-6882-12-195 |
Pubmed ID | |
Authors |
Taghreed N Almanaa, Michael E Geusz, Roudabeh J Jamasbi |
Abstract |
Many cancers contain cell subpopulations that display characteristics of stem cells. Because these cancer stem cells (CSCs) appear to provide resistance to chemo-radiation therapy, development of therapeutic agents that target CSCs is essential. Curcumin is a phytochemical agent that is currently used in clinical trials to test its effectiveness against cancer. However, the effect of curcumin on CSCs is not well established. The current study evaluated curcumin-induced cell death in six cancer cell lines derived from human esophageal squamous cell carcinomas. Moreover, these cell lines and the ones established from cells that survived curcumin treatments were characterized. |
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