↓ Skip to main content

Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease

Overview of attention for article published in Alzheimer's Research & Therapy, July 2016
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

news
1 news outlet
twitter
12 tweeters

Citations

dimensions_citation
61 Dimensions

Readers on

mendeley
99 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease
Published in
Alzheimer's Research & Therapy, July 2016
DOI 10.1186/s13195-016-0198-6
Pubmed ID
Authors

Frederic Blanc, Sean J. Colloby, Benjamin Cretin, Paulo Loureiro de Sousa, Catherine Demuynck, John T. O’Brien, Catherine Martin-Hunyadi, Ian McKeith, Nathalie Philippi, John-Paul Taylor

Abstract

Little is known about the patterns of brain atrophy in prodromal dementia with Lewy bodies (pro-DLB). In this study, we used SPM8 with diffeomorphic anatomical registration through exponentiated lie algebra to measure grey matter (GM) volume and investigate patterns of GM atrophy in pro-DLB (n = 28) and prodromal Alzheimer's disease (pro-AD) (n = 27) and compared and contrasted them with those in elderly control subjects (n = 33) (P ≤ 0.05 corrected for family-wise error). Patients with pro-DLB showed diminished GM volumes of bilateral insulae and right anterior cingulate cortex compared with control subjects. Comparison of GM volume between patients with pro-AD and control subjects showed a more extensive pattern, with volume reductions in temporal (hippocampi and superior and middle gyri), parietal and frontal structures in the former. Direct comparison of prodromal groups suggested that more atrophy was evident in the parietal lobes of patients with pro-AD than patients with pro-DLB. In patients with pro-DLB, we found that visual hallucinations were associated with relative atrophy of the left cuneus. Atrophy in pro-DLB involves the insulae and anterior cingulate cortex, regions rich in von Economo neurons, which we speculate may contribute to the early clinical phenotype of pro-DLB.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 1%
Unknown 98 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 14%
Researcher 12 12%
Student > Ph. D. Student 11 11%
Other 9 9%
Student > Bachelor 9 9%
Other 24 24%
Unknown 20 20%
Readers by discipline Count As %
Medicine and Dentistry 21 21%
Psychology 18 18%
Neuroscience 18 18%
Nursing and Health Professions 5 5%
Agricultural and Biological Sciences 4 4%
Other 10 10%
Unknown 23 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2023.
All research outputs
#1,858,026
of 22,994,508 outputs
Outputs from Alzheimer's Research & Therapy
#368
of 1,240 outputs
Outputs of similar age
#36,715
of 364,423 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#6
of 13 outputs
Altmetric has tracked 22,994,508 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,240 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.0. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 364,423 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.