Title |
Genome comparisons provide insights into the role of secondary metabolites in the pathogenic phase of the Photorhabdus life cycle
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Published in |
BMC Genomics, August 2016
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DOI | 10.1186/s12864-016-2862-4 |
Pubmed ID | |
Authors |
Nicholas J. Tobias, Bagdevi Mishra, Deepak K. Gupta, Rahul Sharma, Marco Thines, Timothy P. Stinear, Helge B. Bode |
Abstract |
Bacteria within the genus Photorhabdus maintain mutualistic symbioses with nematodes in complicated lifecycles that also involves insect pathogenic phases. Intriguingly, these bacteria are rich in biosynthetic gene clusters that produce compounds with diverse biological activities. As a basis to better understand the life cycles of Photorhabdus we sequenced the genomes of two recently discovered representative species and performed detailed genomic comparisons with five publically available genomes. Here we report the genomic details of two new reference Photorhabdus species. By then conducting genomic comparisons across the genus, we show that there are several highly conserved biosynthetic gene clusters. These clusters produce a range of bioactive small molecules that support the pathogenic phase of the integral relationship that Photorhabdus maintain with nematodes. Photorhabdus contain several genetic loci that allow them to become specialist insect pathogens by efficiently evading insect immune responses and killing the insect host. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Colombia | 1 | 2% |
Unknown | 45 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 10 | 22% |
Researcher | 8 | 17% |
Student > Bachelor | 5 | 11% |
Student > Ph. D. Student | 5 | 11% |
Professor | 2 | 4% |
Other | 4 | 9% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 21 | 46% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Immunology and Microbiology | 5 | 11% |
Nursing and Health Professions | 1 | 2% |
Neuroscience | 1 | 2% |
Other | 0 | 0% |
Unknown | 12 | 26% |