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Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke

Overview of attention for article published in Respiratory Research, August 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (56th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

twitter
4 tweeters
facebook
1 Facebook page

Citations

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13 Dimensions

Readers on

mendeley
20 Mendeley
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Title
Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke
Published in
Respiratory Research, August 2016
DOI 10.1186/s12931-016-0416-6
Pubmed ID
Authors

Danya Thayaparan, Pamela Shen, Martin R. Stämpfli, Mathieu C. Morissette

Abstract

Chronic cigarette smoke exposure is known to activate the adaptive immune system; however, the functional role of these processes is currently unknown. Given the role of oxidized lipids in driving innate inflammatory responses to cigarette smoke, we investigated whether an adaptive immune response against damaged lipids was induced following chronic cigarette smoke exposure. Using a well-established mouse model, we showed that cigarette smoke exposure led to a progressive increase in pulmonary antibodies against oxidized low-density lipoprotein (OxLDL). Functionally, we found that intranasal delivery of an antibody against oxidized phosphatidylcholine (anti-OxPC; clone E06) increased lipid and particle uptake by pulmonary macrophages without exacerbating cigarette smoke-induced neutrophilia. We also found that anti-OxPC treatment increased particle uptake following smoking cessation. Finally, the frequency of pulmonary macrophages with internalized particles was increased after prolonged smoke exposure, at which time lung anti-OxPC responses were highest. Altogether, this is the first report to demonstrate a non-pathogenic, and possibly protective, function of a newly identified autoantibody induced by chronic cigarette smoke exposure.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 20%
Student > Master 4 20%
Researcher 3 15%
Student > Ph. D. Student 3 15%
Student > Doctoral Student 1 5%
Other 2 10%
Unknown 3 15%
Readers by discipline Count As %
Medicine and Dentistry 5 25%
Agricultural and Biological Sciences 3 15%
Immunology and Microbiology 2 10%
Biochemistry, Genetics and Molecular Biology 2 10%
Environmental Science 1 5%
Other 2 10%
Unknown 5 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2017.
All research outputs
#9,211,905
of 16,741,199 outputs
Outputs from Respiratory Research
#1,041
of 2,127 outputs
Outputs of similar age
#115,830
of 268,559 outputs
Outputs of similar age from Respiratory Research
#3
of 8 outputs
Altmetric has tracked 16,741,199 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,127 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,559 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.