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Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome

Overview of attention for article published in Molecular Brain, August 2016
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Title
Synaptic plasticity and spatial working memory are impaired in the CD mouse model of Williams-Beuren syndrome
Published in
Molecular Brain, August 2016
DOI 10.1186/s13041-016-0258-7
Pubmed ID
Authors

Cristina Borralleras, Susana Mato, Thierry Amédée, Carlos Matute, Christophe Mulle, Luis A. Pérez-Jurado, Victoria Campuzano

Abstract

Mice heterozygous for a complete deletion (CD) equivalent to the most common deletion found in individuals with Williams-Beuren syndrome (WBS) recapitulate relevant features of the neurocognitive phenotype, such as hypersociability, along with some neuroanatomical alterations in specific brain areas. However, the pathophysiological mechanisms underlying these phenotypes still remain largely unknown. We have studied the synaptic function and cognition in CD mice using hippocampal slices and a behavioral test sensitive to hippocampal function. We have found that long-term potentiation (LTP) elicited by theta burst stimulation (TBS) was significantly impaired in hippocampal field CA1 of CD animals. This deficit might be associated with the observed alterations in spatial working memory. However, we did not detect changes in presynaptic function, LTP induction mechanisms or AMPA and NMDA receptor function. Reduced levels of Brain-derived neurotrophic factor (BDNF) were present in the CA1-CA3 hippocampal region of CD mice, which could account for LTP deficits in these mice. Taken together, these results suggest a defect of CA1 synapses in CD mice to sustain synaptic strength after stimulation. These data represent the first description of synaptic functional deficits in CD mice and further highlights the utility of the CD model to study the mechanisms underlying the WBS neurocognitive profile.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Italy 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 19%
Researcher 8 15%
Student > Bachelor 6 11%
Other 4 7%
Student > Master 4 7%
Other 7 13%
Unknown 15 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 15%
Neuroscience 8 15%
Agricultural and Biological Sciences 7 13%
Medicine and Dentistry 5 9%
Psychology 3 6%
Other 5 9%
Unknown 18 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2016.
All research outputs
#17,811,816
of 22,881,964 outputs
Outputs from Molecular Brain
#749
of 1,112 outputs
Outputs of similar age
#269,076
of 366,909 outputs
Outputs of similar age from Molecular Brain
#11
of 15 outputs
Altmetric has tracked 22,881,964 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,112 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
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We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.