Title |
REM sleep behavior disorder was associated with Parkinson’s disease: a community-based study
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Published in |
BMC Neurology, August 2016
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DOI | 10.1186/s12883-016-0640-1 |
Pubmed ID | |
Authors |
Jian-Fang Ma, Miao-Miao Hou, Hui-Dong Tang, Xiang Gao, Liang Liang, Li-Fang Zhu, Yi Zhou, Sheng-Yu Zha, Shi-Shuang Cui, Juan-Juan Du, Gen Li, Jun Liu, Sheng-Di Chen |
Abstract |
Our study was aimed to validate a modified RBD (REM sleep behavior disorder) single question (RBD1Q-C), study the prevalence of probable RBD (pRBD) in a rural community based on RBD1Q-C and investigate the association between pRBD and Parkinson's disease (PD). The validation study of RBD1Q-C included 32 Chinese participants (14 idiopathic RBD patients and 18 controls). All participants underwent a polysomnogram (PSG). We then conducted a door-to-door survey to estimate the prevalence of pRBD assessed by RBD1Q-C, and its association with PD among 19614 residents who lived in Malu community of Shanghai, China. RBD1Q-C demonstrated a high sensitivity of 100 %, a moderate specificity of 55.6 %. The agreement between RBD1Q-C and PSG-based RBD diagnosis was good (k = 0.552). PPV of the RBD1Q-C was 63.6 % and NPV was 100 %. The prevalence of pRBD in Malu community was 4.9 %. In people over 50 years old, presence of pRBD was significantly associated with increased risk of having PD (odds ratio = 2.61, 95 % CI: 1.56-4.39). RBD1Q-C was shown to be a useful screening tool. Based on the RBD1Q-C, we found that pRBD was not rare in Chinese rural population and associated with odds of PD, calling for more attention from patients, caregivers and physicians. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 43 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 10 | 23% |
Student > Ph. D. Student | 5 | 11% |
Researcher | 5 | 11% |
Student > Master | 5 | 11% |
Student > Doctoral Student | 3 | 7% |
Other | 2 | 5% |
Unknown | 14 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 27% |
Psychology | 5 | 11% |
Neuroscience | 5 | 11% |
Engineering | 3 | 7% |
Social Sciences | 2 | 5% |
Other | 3 | 7% |
Unknown | 14 | 32% |