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New insights into signalling networks regulating breast cancer stem cells

Overview of attention for article published in Breast Cancer Research, September 2012
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Title
New insights into signalling networks regulating breast cancer stem cells
Published in
Breast Cancer Research, September 2012
DOI 10.1186/bcr3209
Pubmed ID
Authors

Alexander Swarbrick, Roger J Daly

Abstract

In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 8%
Australia 1 8%
Unknown 10 83%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 50%
Student > Ph. D. Student 2 17%
Student > Postgraduate 2 17%
Student > Bachelor 1 8%
Unknown 1 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 75%
Medicine and Dentistry 2 17%
Unknown 1 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2012.
All research outputs
#22,760,732
of 25,374,917 outputs
Outputs from Breast Cancer Research
#1,883
of 2,053 outputs
Outputs of similar age
#169,972
of 189,237 outputs
Outputs of similar age from Breast Cancer Research
#30
of 34 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,053 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,237 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.