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A transcriptional blueprint for a spiral-cleaving embryo

Overview of attention for article published in BMC Genomics, August 2016
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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12 tweeters

Citations

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16 Dimensions

Readers on

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33 Mendeley
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Title
A transcriptional blueprint for a spiral-cleaving embryo
Published in
BMC Genomics, August 2016
DOI 10.1186/s12864-016-2860-6
Pubmed ID
Authors

Hsien-Chao Chou, Margaret M. Pruitt, Benjamin R. Bastin, Stephan Q. Schneider

Abstract

The spiral cleavage mode of early development is utilized in over one-third of all animal phyla and generates embryonic cells of different size, position, and fate through a conserved set of stereotypic and invariant asymmetric cell divisions. Despite the widespread use of spiral cleavage, regulatory and molecular features for any spiral-cleaving embryo are largely uncharted. To address this gap we use RNA-sequencing on the spiralian model Platynereis dumerilii to capture and quantify the first complete genome-wide transcriptional landscape of early spiral cleavage. RNA-sequencing datasets from seven stages in early Platynereis development, from the zygote to the protrochophore, are described here including the de novo assembly and annotation of ~17,200 Platynereis genes. Depth and quality of the RNA-sequencing datasets allow the identification of the temporal onset and level of transcription for each annotated gene, even if the expression is restricted to a single cell. Over 4000 transcripts are maternally contributed and cleared by the end of the early spiral cleavage phase. Small early waves of zygotic expression are followed by major waves of thousands of genes, demarcating the maternal to zygotic transition shortly after the completion of spiral cleavages in this annelid species. Our comprehensive stage-specific transcriptional analysis of early embryonic stages in Platynereis elucidates the regulatory genome during early spiral embryogenesis and defines the maternal to zygotic transition in Platynereis embryos. This transcriptome assembly provides the first systems-level view of the transcriptional and regulatory landscape for a spiral-cleaving embryo.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 24%
Student > Ph. D. Student 6 18%
Student > Bachelor 5 15%
Student > Master 3 9%
Student > Doctoral Student 2 6%
Other 3 9%
Unknown 6 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 39%
Biochemistry, Genetics and Molecular Biology 10 30%
Environmental Science 1 3%
Philosophy 1 3%
Economics, Econometrics and Finance 1 3%
Other 0 0%
Unknown 7 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2016.
All research outputs
#1,379,776
of 8,629,768 outputs
Outputs from BMC Genomics
#908
of 6,039 outputs
Outputs of similar age
#57,524
of 260,877 outputs
Outputs of similar age from BMC Genomics
#45
of 273 outputs
Altmetric has tracked 8,629,768 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,039 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,877 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 273 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.