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Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia

Overview of attention for article published in Arthritis Research & Therapy, January 2012
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Title
Noninvasive optical characterization of muscle blood flow, oxygenation, and metabolism in women with fibromyalgia
Published in
Arthritis Research & Therapy, January 2012
DOI 10.1186/ar4079
Pubmed ID
Authors

Yu Shang, Katelyn Gurley, Brock Symons, Douglas Long, Ratchakrit Srikuea, Leslie J Crofford, Charlotte A Peterson, Guoqiang Yu

Abstract

ABSTRACT: INTRODUCTION: Women with fibromyalgia (FM) have symptoms of increased muscular fatigue and reduced exercise tolerance, which may be associated with alterations in muscle microcirculation and oxygen metabolism. This study used near-infrared diffuse optical spectroscopies to noninvasively evaluate muscle blood flow, blood oxygenation and oxygen metabolism during leg fatiguing exercise and during arm arterial cuff occlusion in post-menopausal women with and without FM. METHODS: Fourteen women with FM and twenty-three well-matched healthy controls participated in this study. For the fatiguing exercise protocol, the subject was instructed to perform 6 sets of 12 isometric contractions of knee extensor muscles with intensity steadily increasing from 20 to 70% maximal voluntary isometric contraction (MVIC). For the cuff occlusion protocol, forearm arterial blood flow was occluded via a tourniquet on the upper arm for 3 minutes. Leg or arm muscle hemodynamics, including relative blood flow (rBF), oxy- and deoxy-hemoglobin concentration ([HbO2] and [Hb]), total hemoglobin concentration (THC) and blood oxygen saturation (StO2), were continuously monitored throughout protocols using a custom-built hybrid diffuse optical instrument that combined a commercial near-infrared oximeter for tissue oxygenation measurements and a custom-designed diffuse correlation spectroscopy (DCS) flowmeter for tissue blood flow measurements. Relative oxygen extraction fraction (rOEF) and oxygen consumption rate (rVO2) were calculated from the measured blood flow and oxygenation data. Post-manipulation (fatiguing exercise or cuff occlusion) recovery in muscle hemodynamics was characterized by the recovery half-time, a time interval from the end of manipulation to the time that tissue hemodynamics reached a half-maximal value. RESULTS: Subjects with FM had similar hemodynamic and metabolic response/recovery patterns as healthy controls during exercise and during arterial occlusion. However, tissue rOEF during exercise in subjects with FM was significantly lower than in healthy controls, and the half-times of oxygenation recovery (Δ[HbO2] and Δ[Hb]) were significantly longer following fatiguing exercise and cuff occlusion. CONCLUSIONS: Our results suggest an alteration of muscle oxygen utilization in the FM population. This study demonstrates the potential of using combined diffuse optical spectroscopies (i.e., NIRS/DCS) to comprehensively evaluate tissue oxygen and flow kinetics in skeletal muscle.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 2 2%
United Kingdom 2 2%
Brazil 1 <1%
Australia 1 <1%
Netherlands 1 <1%
Germany 1 <1%
United States 1 <1%
Unknown 103 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 20%
Student > Bachelor 18 16%
Researcher 12 11%
Student > Ph. D. Student 11 10%
Other 8 7%
Other 22 20%
Unknown 19 17%
Readers by discipline Count As %
Medicine and Dentistry 32 29%
Sports and Recreations 17 15%
Nursing and Health Professions 7 6%
Neuroscience 6 5%
Social Sciences 4 4%
Other 18 16%
Unknown 28 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2012.
All research outputs
#15,150,434
of 18,922,407 outputs
Outputs from Arthritis Research & Therapy
#2,298
of 2,711 outputs
Outputs of similar age
#126,738
of 170,168 outputs
Outputs of similar age from Arthritis Research & Therapy
#3
of 4 outputs
Altmetric has tracked 18,922,407 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,711 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,168 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.