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Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage

Overview of attention for article published in Journal of Neuroinflammation, April 2015
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Title
Mature oligodendrocytes actively increase in vivo cytoskeletal plasticity following CNS damage
Published in
Journal of Neuroinflammation, April 2015
DOI 10.1186/s12974-015-0271-2
Pubmed ID
Authors

Giuseppe Locatelli, Arianna Baggiolini, Bettina Schreiner, Pushpalatha Palle, Ari Waisman, Burkhard Becher, Thorsten Buch

Abstract

Oligodendrocytes are myelinating cells of the central nervous system which support functionally, structurally, and metabolically neurons. Mature oligodendrocytes are generally believed to be mere targets of destruction in the context of neuroinflammation and tissue damage, but their real degree of in vivo plasticity has become a matter of debate. We thus investigated the in vivo dynamic, actin-related response of these cells under different kinds of demyelinating stress. We used a novel mouse model (oLucR) expressing luciferase in myelin oligodendrocyte glycoprotein-positive oligodendrocytes under the control of a β-actin promoter. Activity of this promoter served as surrogate for dynamics of the cytoskeleton gene transcription through recording of in vivo bioluminescence following diphtheria toxin-induced oligodendrocyte death and autoimmune demyelination. Cytoskeletal gene expression was quantified from mature oligodendrocytes directly isolated from transgenic animals through cell sorting. Experimental demyelinating setups augmented oligodendrocyte-specific in vivo bioluminescence. These changes in luciferase signal were confirmed by further ex vivo analysis of the central nervous system tissue from oLucR mice. Increase in bioluminescence upon autoimmune inflammation was parallel to an oligodendrocyte-specific increased transcription of β-tubulin. Mature oligodendrocytes acutely increase their cytoskeletal plasticity in vivo during demyelination. They are therefore not passive players under demyelinating conditions but can rather react dynamically to external insults.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 26%
Student > Postgraduate 4 13%
Student > Doctoral Student 3 10%
Student > Master 3 10%
Student > Bachelor 2 6%
Other 4 13%
Unknown 7 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 26%
Neuroscience 5 16%
Immunology and Microbiology 3 10%
Medicine and Dentistry 3 10%
Veterinary Science and Veterinary Medicine 2 6%
Other 3 10%
Unknown 7 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2016.
All research outputs
#18,467,278
of 22,882,389 outputs
Outputs from Journal of Neuroinflammation
#2,077
of 2,644 outputs
Outputs of similar age
#193,058
of 263,859 outputs
Outputs of similar age from Journal of Neuroinflammation
#43
of 50 outputs
Altmetric has tracked 22,882,389 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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