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DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells

Overview of attention for article published in BMC Immunology, November 2012
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Title
DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells
Published in
BMC Immunology, November 2012
DOI 10.1186/1471-2172-13-58
Pubmed ID
Authors

Guoying Wu, Keiji Hirabayashi, Shinya Sato, Nobuko Akiyama, Taishin Akiyama, Kunio Shiota, Shintaro Yagi

Abstract

Medullary thymic epithelial cells (mTECs) are characterized by ectopic expression of self-antigens during the establishment of central tolerance. The autoimmune regulator (Aire), which is specifically expressed in mTECs, is responsible for the expression of a large repertoire of tissue-restricted antigens (TRAs) and plays a role in the development of mTECs. However, Aire-deficient mTECs still express TRAs. Moreover, a subset of mTECs, which are considered to be at a stage of terminal differentiation, exists in the Aire-deficient thymus. The phenotype of a specific cell type in a multicellular organism is governed by the epigenetic regulation system. DNA methylation modification is an important component of this system. Every cell or tissue type displays a DNA methylation profile, consisting of tissue-dependent and differentially methylated regions (T-DMRs), and this profile is involved in cell-type-specific genome usage. The aim of this study was to examine the DNA methylation profile of mTECs by using Aire-deficient mTECs as a model.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Brazil 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 23%
Researcher 6 20%
Student > Master 6 20%
Professor 4 13%
Student > Postgraduate 2 7%
Other 3 10%
Unknown 2 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 50%
Biochemistry, Genetics and Molecular Biology 6 20%
Medicine and Dentistry 3 10%
Immunology and Microbiology 1 3%
Unknown 5 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2012.
All research outputs
#9,905,970
of 12,373,180 outputs
Outputs from BMC Immunology
#316
of 425 outputs
Outputs of similar age
#97,953
of 138,532 outputs
Outputs of similar age from BMC Immunology
#2
of 2 outputs
Altmetric has tracked 12,373,180 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 425 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
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