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Factors related to outcome of bloodstream infections due to Candida parapsilosis complex

Overview of attention for article published in BMC Infectious Diseases, August 2016
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Title
Factors related to outcome of bloodstream infections due to Candida parapsilosis complex
Published in
BMC Infectious Diseases, August 2016
DOI 10.1186/s12879-016-1704-y
Pubmed ID
Authors

Francesco Barchiesi, Elena Orsetti, Patrizia Osimani, Carlo Catassi, Fabio Santelli, Esther Manso

Abstract

Although Candida albicans is the most common cause of fungal blood stream infections (BSIs), infections due to Candida species other than C. albicans are rising. Candida parapsilosis complex has emerged as an important fungal pathogen and became one of the main causes of fungemia in specific geographical areas. We analyzed the factors related to outcome of candidemia due to C. parapsilosis in a single tertiary referral hospital over a five-year period. A retrospective observational study of all cases of candidemia was carried out at a 980-bedded University Hospital in Italy. Data regarding demographic characteristics and clinical risk factors were collected from the patient's medical records. Antifungal susceptibility testing was performed and MIC results were interpreted according to CLSI species-specific clinical breakpoints. Of 270 patients diagnosed with Candida BSIs during the study period, 63 (23 %) were infected with isolates of C. parapsilosis complex which represented the second most frequently isolated yeast after C. albicans. The overall incidence rate was 0.4 episodes/1000 hospital admissions. All the strains were in vitro susceptible to all antifungal agents. The overall crude mortality at 30 days was 27 % (17/63), which was significantly lower than that reported for C. albicans BSIs (42 % [61/146], p = 0.042). Being hospitalized in ICU resulted independently associated with a significant higher risk of mortality (HR 4.625 [CI95% 1.015-21.080], p = 0.048). Conversely, early CVC removal was confirmed to be significantly associated with a lower risk of mortality (HR 0.299 [CI95% 0.102-0.874], p = 0.027). Finally, the type of primary antifungal therapy did not influence the outcome of infection. Candidemia due to C. parapsilosis complex, the second most commonly causative agent of yeast BSIs in our center, is characterized by a non-negligible mortality at 30 days. An early CVC removal is associated with a significant reduced mortality.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 14%
Researcher 8 11%
Student > Doctoral Student 8 11%
Student > Postgraduate 7 10%
Student > Bachelor 7 10%
Other 15 21%
Unknown 18 25%
Readers by discipline Count As %
Medicine and Dentistry 18 25%
Immunology and Microbiology 10 14%
Agricultural and Biological Sciences 5 7%
Nursing and Health Professions 4 5%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Other 6 8%
Unknown 27 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2019.
All research outputs
#17,812,370
of 22,882,389 outputs
Outputs from BMC Infectious Diseases
#5,126
of 7,690 outputs
Outputs of similar age
#264,519
of 361,768 outputs
Outputs of similar age from BMC Infectious Diseases
#113
of 177 outputs
Altmetric has tracked 22,882,389 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,690 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,768 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 177 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.