Title |
Custom genotyping for substance addiction susceptibility genes in Jordanians of Arab descent
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Published in |
BMC Research Notes, September 2012
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DOI | 10.1186/1756-0500-5-497 |
Pubmed ID | |
Authors |
Laith N AL-Eitan, Saied A Jaradat, Gary K Hulse, Guan K Tay |
Abstract |
Both environmental and genetic factors contribute to individual susceptibility to initiation of substance use and vulnerability to addiction. Determining genetic risk factors can make an important contribution to understanding the processes leading to addiction. In order to identify gene(s) and mechanisms associated with substance addiction, a custom platform array search for a genetic association in a case/control of homogenous Jordanian Arab population was undertaken. Patients meeting the DSM-VI criteria for substance dependence (n = 220) and entering eight week treatment program at two Jordanian Drug Rehabilitation Centres were genotyped. In addition, 240 healthy controls were also genotyped. The sequenom MassARRAY system (iPLEX GOLD) was used to genotype 49 single nucleotide polymorphisms (SNPs) within 8 genes (DRD1, DRD2, DRD3, DRD4, DRD5, BDNF, SLC6A3 and COMT). |
X Demographics
Geographical breakdown
Country | Count | As % |
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Côte d'Ivoire | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 2% |
Unknown | 41 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 12% |
Student > Bachelor | 5 | 12% |
Other | 4 | 10% |
Student > Master | 4 | 10% |
Student > Ph. D. Student | 3 | 7% |
Other | 10 | 24% |
Unknown | 11 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 14% |
Agricultural and Biological Sciences | 6 | 14% |
Medicine and Dentistry | 5 | 12% |
Social Sciences | 4 | 10% |
Psychology | 2 | 5% |
Other | 6 | 14% |
Unknown | 13 | 31% |