Title |
The complex cascade of cellular events governing inflammasome activation and IL-1β processing in response to inhaled particles
|
---|---|
Published in |
Particle and Fibre Toxicology, August 2016
|
DOI | 10.1186/s12989-016-0150-8 |
Pubmed ID | |
Authors |
Virginie Rabolli, Dominique Lison, François Huaux |
Abstract |
The innate immune system is the first line of defense against inhaled particles. Macrophages serve important roles in particle clearance and inflammatory reactions. Following recognition and internalization by phagocytes, particles are taken up in vesicular phagolysosomes. Intracellular phagosomal leakage, redox unbalance and ionic movements induced by toxic particles result in pro-IL-1β expression, inflammasome complex engagement, caspase-1 activation, pro-IL-1β cleavage, biologically-active IL-1β release and finally inflammatory cell death termed pyroptosis. In this review, we summarize the emerging signals and pathways involved in the expression, maturation and secretion of IL-1β during these responses to particles. We also highlight physicochemical characteristics of particles (size, surface and shape) which determine their capacity to induce inflammasome activation and IL-1β processing. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 25% |
Researcher | 11 | 16% |
Student > Bachelor | 6 | 9% |
Student > Master | 6 | 9% |
Student > Doctoral Student | 4 | 6% |
Other | 11 | 16% |
Unknown | 13 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 14 | 21% |
Medicine and Dentistry | 10 | 15% |
Immunology and Microbiology | 8 | 12% |
Agricultural and Biological Sciences | 5 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 10 | 15% |
Unknown | 18 | 26% |