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Older patients are still under-represented in clinical trials of Alzheimer’s disease

Overview of attention for article published in Alzheimer's Research & Therapy, August 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)

Mentioned by

1 news outlet
28 tweeters


35 Dimensions

Readers on

51 Mendeley
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Older patients are still under-represented in clinical trials of Alzheimer’s disease
Published in
Alzheimer's Research & Therapy, August 2016
DOI 10.1186/s13195-016-0201-2
Pubmed ID

Rita Banzi, Paolo Camaioni, Mauro Tettamanti, Vittorio Bertele’, Ugo Lucca


The age gap between participants in trials and patients who could benefit from the drugs studied has been widely documented across different clinical areas. Patients with dementia included in clinical research are systematically younger than those in the general population. We examined the age gap between participants in recent clinical trials testing interventions for Alzheimer's disease and epidemiological data. We systematically searched literature databases (MedLine, EMBASE, the Cochrane Library) and ClinicalTrials.gov from 2000 to July 2015 to retrieve clinical trials testing pharmacologic treatments for Alzheimer's disease, other than cholinesterase inhibitors and memantine. We included ongoing and completed phase II/III randomized clinical trials, irrespective of their publication status. From each study reporting the participants' ages, we extracted size of sample, mean age, and standard deviation, and estimated the proportions of participants in different age classes. The number of patients with Alzheimer's disease by age class in the USA population was used for comparison. We included 165 clinical trials testing almost 100 different compounds, which enrolled or planned to enroll about 74,300 participants. Seventy-nine of these trials, accounting for about 26,800 participants, reported the age of the participants. The weighted mean age was 73.6 years (standard deviation, 8.2). People younger than 80 years were highly represented in clinical trials (78 %), despite the fact that those aged 80 and older form the majority (72 %) of patients with Alzheimer's disease. Only 8 % of clinical trial participants were 85 years or older. Patients enrolled in clinical trials on Alzheimer's disease are far from being representative of actual distribution of the patients in the general population. Clinical research should not be designed and conducted overlooking the fact that the majority of individuals with Alzheimer's disease are likely to be 80 or older.

Twitter Demographics

The data shown below were collected from the profiles of 28 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 51 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 16%
Student > Master 8 16%
Student > Bachelor 7 14%
Other 4 8%
Student > Postgraduate 4 8%
Other 7 14%
Unknown 13 25%
Readers by discipline Count As %
Medicine and Dentistry 12 24%
Pharmacology, Toxicology and Pharmaceutical Science 5 10%
Neuroscience 3 6%
Psychology 3 6%
Nursing and Health Professions 2 4%
Other 7 14%
Unknown 19 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 28. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2016.
All research outputs
of 21,377,679 outputs
Outputs from Alzheimer's Research & Therapy
of 1,103 outputs
Outputs of similar age
of 280,809 outputs
Outputs of similar age from Alzheimer's Research & Therapy
of 1 outputs
Altmetric has tracked 21,377,679 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,809 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them