Title |
Stochastic simulations of minimal cells: the Ribocell model
|
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Published in |
BMC Bioinformatics, March 2012
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DOI | 10.1186/1471-2105-13-s4-s10 |
Pubmed ID | |
Authors |
Fabio Mavelli |
Abstract |
Over the last two decades, lipid compartments (liposomes, lipid-coated droplets) have been extensively used as in vitro "minimal" cell models. In particular, simple and complex biomolecular reactions have been carried out inside these self-assembled micro- and nano-sized compartments, leading to the synthesis of RNA and functional proteins inside liposomes. Despite this experimental progress, a detailed physical understanding of the underlying dynamics is missing. In particular, the combination of solute compartmentalization, reactivity and stochastic effects has not yet been clarified. A combination of experimental and computational approaches can reveal interesting mechanisms governing the behavior of micro compartmentalized systems, in particular by highlighting the intrinsic stochastic diversity within a population of "synthetic cells". |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Unknown | 28 | 100% |
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Student > Ph. D. Student | 8 | 29% |
Researcher | 6 | 21% |
Student > Master | 5 | 18% |
Student > Bachelor | 3 | 11% |
Student > Doctoral Student | 2 | 7% |
Other | 2 | 7% |
Unknown | 2 | 7% |
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Physics and Astronomy | 3 | 11% |
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Engineering | 2 | 7% |
Other | 1 | 4% |
Unknown | 3 | 11% |