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CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller

Overview of attention for article published in Retrovirology, November 2012
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Title
CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller
Published in
Retrovirology, November 2012
DOI 10.1186/1742-4690-9-91
Pubmed ID
Authors

Benjamin J Burwitz, Juan Pablo Giraldo-Vela, Jason Reed, Laura P Newman, Alexander T Bean, Francesca A Nimityongskul, Philip A Castrovinci, Nicholas J Maness, Enrique J Leon, Richard Rudersdorf, Jonah B Sacha

Abstract

Virus-specific T cells are critical components in the containment of immunodeficiency virus infections. While the protective role of CD8+ T cells is well established by studies of CD8+ T cell-mediated viral escape, it remains unknown if CD4+ T cells can also impose sufficient selective pressure on replicating virus to drive the emergence of high-frequency escape variants. Identifying a high frequency CD4+ T cell driven escape mutation would provide compelling evidence of direct immunological pressure mediated by these cells.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 30%
Student > Master 4 13%
Student > Ph. D. Student 3 10%
Student > Doctoral Student 3 10%
Student > Bachelor 2 7%
Other 3 10%
Unknown 6 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 30%
Immunology and Microbiology 8 27%
Biochemistry, Genetics and Molecular Biology 3 10%
Medicine and Dentistry 3 10%
Engineering 1 3%
Other 0 0%
Unknown 6 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 November 2012.
All research outputs
#15,256,044
of 22,685,926 outputs
Outputs from Retrovirology
#776
of 1,103 outputs
Outputs of similar age
#115,491
of 183,491 outputs
Outputs of similar age from Retrovirology
#11
of 16 outputs
Altmetric has tracked 22,685,926 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,103 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,491 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.