Title |
CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller
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Published in |
Retrovirology, November 2012
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DOI | 10.1186/1742-4690-9-91 |
Pubmed ID | |
Authors |
Benjamin J Burwitz, Juan Pablo Giraldo-Vela, Jason Reed, Laura P Newman, Alexander T Bean, Francesca A Nimityongskul, Philip A Castrovinci, Nicholas J Maness, Enrique J Leon, Richard Rudersdorf, Jonah B Sacha |
Abstract |
Virus-specific T cells are critical components in the containment of immunodeficiency virus infections. While the protective role of CD8+ T cells is well established by studies of CD8+ T cell-mediated viral escape, it remains unknown if CD4+ T cells can also impose sufficient selective pressure on replicating virus to drive the emergence of high-frequency escape variants. Identifying a high frequency CD4+ T cell driven escape mutation would provide compelling evidence of direct immunological pressure mediated by these cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 9 | 30% |
Student > Master | 4 | 13% |
Student > Ph. D. Student | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Student > Bachelor | 2 | 7% |
Other | 3 | 10% |
Unknown | 6 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 30% |
Immunology and Microbiology | 8 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Medicine and Dentistry | 3 | 10% |
Engineering | 1 | 3% |
Other | 0 | 0% |
Unknown | 6 | 20% |