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Co-circulation of the dengue with chikungunya virus during the 2013 outbreak in the southern part of Lao PDR

Overview of attention for article published in Tropical Medicine & Health, August 2016
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Title
Co-circulation of the dengue with chikungunya virus during the 2013 outbreak in the southern part of Lao PDR
Published in
Tropical Medicine & Health, August 2016
DOI 10.1186/s41182-016-0020-y
Pubmed ID
Authors

Viengvaly Phommanivong, Seiji Kanda, Takaki Shimono, Pheophet Lamaningao, Andrew Waleluma Darcy, Nobuyuki Mishima, Bounthanh Phaytanavanh, Toshimasa Nishiyama

Abstract

During the 2013 outbreak, 4638 infection cases and 32 deaths have been recorded in the southern part of Laos. In recent years, the chikungunya virus (CHIKV) emerged in the part of the country bordering Cambodia. Dengue virus (DENV) and CHIKV are transmitted by common mosquito vectors. Both diseases have similar clinical presentations; therefore, CHIKV infections might go undiagnosed in DENV-endemic areas. Thus, rapid detection and accurate diagnosis are crucial for differentiating between the two viruses (DENV and CHIKV). In this study, we demonstrated that CHIKV and two serotypes of DENV are circulating in Laos. In addition, we encountered patients that had been concurrently infected with multiple DENV serotypes or DENV and CHIKV. Plasma samples were collected from 40 patients with suspected DENV infections during an outbreak between July and August 2013. The reverse transcription polymerase chain reaction was performed to detect the four DENV serotypes and CHIKV using specific primers. Specifically, the complete envelope gene sequences of the viruses were sequenced and subjected to phylogenetic analysis. Forty acute-phase plasma samples from patients with suspected dengue infections were tested for the presence of DENV viral RNA using molecular methods. Among the 40 samples, 14 samples were positive for DENV, 2 samples were positive for both viruses (DENV-2 and DENV-3), whereas DENV-1 and DENV-4 were not detected during the study period. We also encountered 10 samples that were positive for CHIKV. Of the 10 CHIKV-positive samples, 3 samples were co-infected by DENV-2, and 2 samples were co-infected by DENV-3. Phylogenetic analysis revealed that the 2013 dengue outbreak in Laos involved DENV-2 genotype Asian I and DENV-3 genotype II. Moreover, the Laotian CHIKV strains grouped together with those isolated during outbreaks on the Indian Ocean Islands within the East Central South African genotype. These findings revealed that two serotypes (DENV-2 and DENV-3) and CHIKV were detected. Furthermore, infection of multiple DENV serotypes and CHIKV was also observed in the 2013 dengue outbreak. This is the first documented evidence of co-infection with CHIKV and one of two DENV serotypes.

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Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 22%
Student > Bachelor 7 12%
Student > Master 6 10%
Other 5 8%
Student > Ph. D. Student 4 7%
Other 10 17%
Unknown 14 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 22%
Agricultural and Biological Sciences 9 15%
Medicine and Dentistry 7 12%
Immunology and Microbiology 5 8%
Nursing and Health Professions 3 5%
Other 9 15%
Unknown 13 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 August 2016.
All research outputs
#13,299,656
of 15,059,695 outputs
Outputs from Tropical Medicine & Health
#146
of 178 outputs
Outputs of similar age
#184,774
of 220,529 outputs
Outputs of similar age from Tropical Medicine & Health
#3
of 3 outputs
Altmetric has tracked 15,059,695 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 178 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 220,529 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.