HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

#HDAC4 degradation during senescence unleashes an #epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers. https://t.co/7HLfvXNNts

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at se... https://t.co/ShyFVlycxl

Di Giorgio, Brancolini & co present an analysis of HDAC4 during senescence. It binds to enhancers associated with senescence genes. It is degraded during senescence, and artificially degrading it is enough to induce senescence. Re-expression delays agi

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers https://t.co/WcthVNJlU9