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Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

Overview of attention for article published in Biology of Sex Differences, November 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

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Citations

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43 Dimensions

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82 Mendeley
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Title
Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?
Published in
Biology of Sex Differences, November 2012
DOI 10.1186/2042-6410-3-24
Pubmed ID
Authors

Dena B Dubal, Lauren Broestl, Kurtresha Worden

Abstract

Biologic sex and gonadal hormones matter in human aging and diseases of aging such as Alzheimer's - and the importance of studying their influences relates directly to human health. The goal of this article is to review the literature to date on sex and hormones in mouse models of Alzheimer's disease (AD) with an exclusive focus on interpreting the relevance of findings to the human condition. To this end, we highlight advances in AD and in sex and hormone biology, discuss what these advances mean for merging the two fields, review the current mouse model literature, raise major unresolved questions, and offer a research framework that incorporates human reproductive aging for future studies aimed at translational discoveries in this important area. Unraveling human relevant pathways in sex and hormone-based biology may ultimately pave the way to novel and urgently needed treatments for AD and other neurodegenerative diseases.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
France 1 1%
Unknown 80 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 22%
Researcher 14 17%
Student > Bachelor 7 9%
Student > Master 6 7%
Other 4 5%
Other 10 12%
Unknown 23 28%
Readers by discipline Count As %
Neuroscience 15 18%
Agricultural and Biological Sciences 15 18%
Biochemistry, Genetics and Molecular Biology 7 9%
Medicine and Dentistry 6 7%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 6 7%
Unknown 32 39%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2023.
All research outputs
#6,264,736
of 25,373,627 outputs
Outputs from Biology of Sex Differences
#222
of 582 outputs
Outputs of similar age
#46,497
of 199,446 outputs
Outputs of similar age from Biology of Sex Differences
#2
of 5 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 582 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.9. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,446 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.