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Stable expression of promyelocytic leukaemia (PML) protein in telomerase positive MCF7 cells results in alternative lengthening of telomeres phenotype

Overview of attention for article published in Genome Integrity, January 2012
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Citations

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Title
Stable expression of promyelocytic leukaemia (PML) protein in telomerase positive MCF7 cells results in alternative lengthening of telomeres phenotype
Published in
Genome Integrity, January 2012
DOI 10.1186/2041-9414-3-5
Pubmed ID
Authors

Jacklyn W Y Yong, Xiujun Yeo, Md Khan, Martin B Lee, M Prakash Hande

Abstract

Cancer cells can employ telomerase or the alternative lengthening of telomeres (ALT) pathway for telomere maintenance. Cancer cells that use the ALT pathway exhibit distinct phenotypes such as heterogeneous telomeres and specialised Promyelocytic leukaemia (PML) nuclear foci called APBs. In our study, we used wild-type PML and a PML mutant, in which the coiled-coil domain is deleted (PML C/C-), to investigate how these proteins can affect telomere maintenance pathways in cancer cells that use either the telomerase or ALT pathway.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 30%
Professor 2 20%
Unspecified 1 10%
Student > Bachelor 1 10%
Student > Ph. D. Student 1 10%
Other 2 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 50%
Biochemistry, Genetics and Molecular Biology 2 20%
Unspecified 1 10%
Engineering 1 10%
Unknown 1 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 January 2021.
All research outputs
#13,954,648
of 17,489,191 outputs
Outputs from Genome Integrity
#13
of 16 outputs
Outputs of similar age
#117,110
of 159,291 outputs
Outputs of similar age from Genome Integrity
#1
of 1 outputs
Altmetric has tracked 17,489,191 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16 research outputs from this source. They receive a mean Attention Score of 3.5. This one scored the same or higher as 3 of them.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them