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Interventions in Wnt signaling as a novel therapeutic approach to improve myocardial infarct healing

Overview of attention for article published in Fibrogenesis & Tissue Repair, September 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

patent
3 patents
facebook
1 Facebook page

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
31 Mendeley
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Title
Interventions in Wnt signaling as a novel therapeutic approach to improve myocardial infarct healing
Published in
Fibrogenesis & Tissue Repair, September 2012
DOI 10.1186/1755-1536-5-16
Pubmed ID
Authors

Kevin CM Hermans, Evangelos P Daskalopoulos, W Matthijs Blankesteijn

Abstract

Following myocardial infarction, wound healing takes place in the infarct area where the non-viable cardiac tissue is replaced by a scar. Inadequate wound healing or insufficient maintenance of the extracellular matrix in the scar can lead to excessive dilatation of the ventricles, one of the hallmarks of congestive heart failure. Therefore, it is important to better understand the wound-healing process in the heart and to develop new therapeutic agents that target the infarct area in order to maintain an adequate cardiac function. One of these potential novel therapeutic targets is Wnt signaling. Wnt signaling plays an important role in embryonic myocardial development but in the adult heart the pathway is thought to be silent. However, there is increasing evidence that components of the Wnt pathway are re-expressed during cardiac repair, implying a regulatory role. Recently, several studies have been published where the effect of interventions in Wnt signaling on infarct healing has been studied. In this review, we will summarize the results of these studies and discuss the effects of these interventions on the different cell types that are involved in the wound healing process.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 3%
Unknown 30 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 39%
Student > Master 5 16%
Student > Postgraduate 3 10%
Researcher 3 10%
Student > Bachelor 2 6%
Other 3 10%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 39%
Medicine and Dentistry 7 23%
Biochemistry, Genetics and Molecular Biology 6 19%
Business, Management and Accounting 1 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 2 6%
Unknown 2 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2018.
All research outputs
#3,413,714
of 17,360,236 outputs
Outputs from Fibrogenesis & Tissue Repair
#14
of 78 outputs
Outputs of similar age
#29,431
of 158,931 outputs
Outputs of similar age from Fibrogenesis & Tissue Repair
#3
of 16 outputs
Altmetric has tracked 17,360,236 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 78 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 158,931 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.