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Identification of candidate genes related to calanolide biosynthesis by transcriptome sequencing of Calophyllum brasiliense (Calophyllaceae)

Overview of attention for article published in BMC Plant Biology, August 2016
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Title
Identification of candidate genes related to calanolide biosynthesis by transcriptome sequencing of Calophyllum brasiliense (Calophyllaceae)
Published in
BMC Plant Biology, August 2016
DOI 10.1186/s12870-016-0862-9
Pubmed ID
Authors

Hilda-Beatriz Gómez-Robledo, Francisco Cruz-Sosa, Antonio Bernabé-Antonio, Antonio Guerrero-Analco, José Luis Olivares-Romero, Alexandro Alonso-Sánchez, Emanuel Villafán, Enrique Ibarra-Laclette

Abstract

Calophyllum brasiliense is highlighted as an important resource of calanolides, which are dipyranocoumarins that inhibit the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). Despite having great medicinal importance, enzymes involved in calanolide, biosynthesis and the pathway itself, are still largely unknown. Additionally, no genomic resources exist for this plant species. In this work, we first analyzed the transcriptome of C. brasiliense leaves, stem, and roots using a RNA-seq strategy, which provided a dataset for functional gene mining. According to the structures of the calanolides, putative biosynthetic pathways were proposed. Finally, candidate unigenes in the transcriptome dataset, potentially involved in umbelliferone and calanolide (angular pyranocoumarin) biosynthetic pathways, were screened using mainly homology-based BLAST and phylogenetic analyses. The unigene dataset that was generated in this study provides an important resource for further molecular studies of C. brasiliense, especially for functional analysis of candidate genes involved in the biosynthetic pathways of linear and angular pyranocoumarins.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 17%
Student > Doctoral Student 5 14%
Student > Bachelor 4 11%
Student > Master 4 11%
Professor 4 11%
Other 5 14%
Unknown 8 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 28%
Biochemistry, Genetics and Molecular Biology 8 22%
Chemistry 4 11%
Unspecified 2 6%
Nursing and Health Professions 1 3%
Other 3 8%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2016.
All research outputs
#12,963,262
of 22,882,389 outputs
Outputs from BMC Plant Biology
#857
of 3,265 outputs
Outputs of similar age
#173,823
of 344,199 outputs
Outputs of similar age from BMC Plant Biology
#12
of 46 outputs
Altmetric has tracked 22,882,389 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,265 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,199 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.