Title |
Lung fibroblasts from patients with emphysema show markers of senescence in vitro
|
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Published in |
Respiratory Research, February 2006
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DOI | 10.1186/1465-9921-7-32 |
Pubmed ID | |
Authors |
K-C Müller, L Welker, K Paasch, B Feindt, VJ Erpenbeck, JM Hohlfeld, N Krug, M Nakashima, D Branscheid, H Magnussen, RA Jörres, O Holz |
Abstract |
The loss of alveolar walls is a hallmark of emphysema. As fibroblasts play an important role in the maintenance of alveolar structure, a change in fibroblast phenotype could be involved in the pathogenesis of this disease. In a previous study we found a reduced in vitro proliferation rate and number of population doublings of parenchymal lung fibroblasts from patients with emphysema and we hypothesized that these findings could be related to a premature cellular aging of these cells. In this study, we therefore compared cellular senescence markers and expression of respective genes between lung fibroblasts from patients with emphysema and control patients without COPD. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 1% |
United States | 1 | 1% |
Germany | 1 | 1% |
Unknown | 90 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 16% |
Researcher | 13 | 14% |
Student > Master | 12 | 13% |
Student > Bachelor | 10 | 11% |
Professor > Associate Professor | 10 | 11% |
Other | 19 | 20% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 26 | 28% |
Agricultural and Biological Sciences | 19 | 20% |
Biochemistry, Genetics and Molecular Biology | 18 | 19% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Nursing and Health Professions | 2 | 2% |
Other | 6 | 6% |
Unknown | 18 | 19% |