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Systematic investigation of insertional and deletional RNA-DNA differences in the human transcriptome

Overview of attention for article published in BMC Genomics, November 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

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17 X users

Citations

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22 Dimensions

Readers on

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28 Mendeley
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3 CiteULike
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Title
Systematic investigation of insertional and deletional RNA-DNA differences in the human transcriptome
Published in
BMC Genomics, November 2012
DOI 10.1186/1471-2164-13-616
Pubmed ID
Authors

Cai Chen, Ralf Bundschuh

Abstract

The genomic information which is transcribed into the primary RNA can be altered by RNA editing at the transcriptional or post-transcriptional level, which provides an effective way to create transcript diversity in an organism. Altering can occur through substitutional RNA editing or via the insertion or deletion of nucleotides relative to the original template. Taking advantage of recent high throughput sequencing technology combined with bioinformatics tools, several groups have recently studied the genome-wide substitutional RNA editing profiles in human. However, while insertional/deletional (indel) RNA editing is well known in several lower species, only very scarce evidence supports the existence of insertional editing events in higher organisms such as human, and no previous work has specifically focused on indel differences between RNA and their matching DNA in human. Here, we provide the first study to examine the possibility of genome-wide indel RNA-DNA differences in one human individual, NA12878, whose RNA and matching genome have been deeply sequenced.

X Demographics

X Demographics

The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 2 7%
United States 2 7%
Colombia 1 4%
Unknown 23 82%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 32%
Student > Ph. D. Student 5 18%
Professor > Associate Professor 3 11%
Student > Bachelor 2 7%
Student > Master 1 4%
Other 2 7%
Unknown 6 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 50%
Computer Science 3 11%
Engineering 2 7%
Biochemistry, Genetics and Molecular Biology 1 4%
Materials Science 1 4%
Other 1 4%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2012.
All research outputs
#4,082,380
of 25,374,917 outputs
Outputs from BMC Genomics
#1,428
of 11,244 outputs
Outputs of similar age
#29,037
of 192,733 outputs
Outputs of similar age from BMC Genomics
#25
of 210 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,244 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 192,733 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 210 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.