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Cortisol directly impacts Flavobacterium columnare in vitro growth characteristics

Overview of attention for article published in Veterinary Research, August 2016
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Title
Cortisol directly impacts Flavobacterium columnare in vitro growth characteristics
Published in
Veterinary Research, August 2016
DOI 10.1186/s13567-016-0370-9
Pubmed ID
Authors

Annelies Maria Declercq, Johan Aerts, Bart Ampe, Freddy Haesebrouck, Sarah De Saeger, Annemie Decostere

Abstract

Teleost fish faced with stressful stimuli launch an endocrine stress response through activation of the hypothalamic-pituitary-interrenal axis to release glucocorticoids, in particular cortisol, into the blood. For the majority of bacterial fish pathogens, stress is considered a key factor in disease outbreaks. Based upon studies in mammals, there is considerable evidence to suggest that, besides impairing the immune system, cortisol can have a direct effect on bacterial cells. Hitherto, this intriguing field of microbial endocrinology has remained largely unexplored in aquatic diseases. The present study investigated in vitro the impact of cortisol on phenotypic traits of the fresh water fish pathogen Flavobacterium columnare. Colonies obtained from the highly virulent (HV) isolates resulted in significantly larger and more spreading colonies compared to those from the low virulent (LV) isolates. High cortisol doses added displayed a direct effect on the bacterial cells and induced a significant decrease in colony size. An additional intriguing finding was the inverse relationship between cortisol concentrations added to the broth and the spreading character of colonies retrieved, with higher cortisol doses resulting in less rhizoid to rough and even smooth colony formation (the latter only in the LV trout isolate), suggesting a dose-response effect. The loss of the rhizoid appearance of the F. columnare colonies upon administration of cortisol, and hence the loss of motility, might indicate a phenotypic change to the biofilm state. These findings form the basis for further research on the impact of glucocorticoids on other virulence factors and biofilm formation of F. columnare.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Student > Master 4 19%
Student > Bachelor 3 14%
Researcher 3 14%
Professor 1 5%
Other 2 10%
Unknown 3 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 19%
Biochemistry, Genetics and Molecular Biology 3 14%
Environmental Science 1 5%
Immunology and Microbiology 1 5%
Medicine and Dentistry 1 5%
Other 0 0%
Unknown 11 52%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2017.
All research outputs
#10,747,684
of 13,510,831 outputs
Outputs from Veterinary Research
#629
of 832 outputs
Outputs of similar age
#187,163
of 264,124 outputs
Outputs of similar age from Veterinary Research
#14
of 19 outputs
Altmetric has tracked 13,510,831 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 832 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
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We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.