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Maternally-derived antibodies do not prevent transmission of swine influenza A virus between pigs

Overview of attention for article published in Veterinary Research, August 2016
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Title
Maternally-derived antibodies do not prevent transmission of swine influenza A virus between pigs
Published in
Veterinary Research, August 2016
DOI 10.1186/s13567-016-0365-6
Pubmed ID
Authors

Charlie Cador, Séverine Hervé, Mathieu Andraud, Stéphane Gorin, Frédéric Paboeuf, Nicolas Barbier, Stéphane Quéguiner, Céline Deblanc, Gaëlle Simon, Nicolas Rose

Abstract

A transmission experiment involving 5-week-old specific-pathogen-free (SPF) piglets, with (MDA(+)) or without maternally-derived antibodies (MDA(-)), was carried out to evaluate the impact of passive immunity on the transmission of a swine influenza A virus (swIAV). In each group (MDA(+)/MDA(-)), 2 seeders were placed with 4 piglets in direct contact and 5 in indirect contact (3 replicates per group). Serological kinetics (ELISA) and individual viral shedding (RT-PCR) were monitored for 28 days after infection. MDA waning was estimated using a nonlinear mixed-effects model and survival analysis. Differential transmission rates were estimated depending on the piglets' initial serological status and contact structure (direct contact with pen-mates or indirect airborne contact). The time to MDA waning was 71.3 [52.8-92.1] days on average. The airborne transmission rate was 1.41 [0.64-2.63] per day. The compared shedding pattern between groups showed that MDA(+) piglets had mainly a reduced susceptibility to infection compared to MDA(-) piglets. The resulting reproduction number estimated in MDA(+) piglets (5.8 [1.4-18.9]), although 3 times lower than in MDA(-) piglets (14.8 [6.4-27.1]), was significantly higher than 1. Such an efficient and extended spread of swIAV at the population scale in the presence of MDAs could contribute to swIAV persistence on farms, given the fact that the period when transmission is expected to be impacted by the presence of MDAs can last up to 10 weeks.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 27%
Student > Ph. D. Student 9 20%
Other 5 11%
Student > Master 4 9%
Student > Bachelor 3 7%
Other 5 11%
Unknown 7 16%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 20 44%
Agricultural and Biological Sciences 7 16%
Immunology and Microbiology 3 7%
Biochemistry, Genetics and Molecular Biology 2 4%
Medicine and Dentistry 2 4%
Other 2 4%
Unknown 9 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2016.
All research outputs
#10,730,723
of 14,123,042 outputs
Outputs from Veterinary Research
#613
of 881 outputs
Outputs of similar age
#172,155
of 264,055 outputs
Outputs of similar age from Veterinary Research
#10
of 18 outputs
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We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.