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Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice

Overview of attention for article published in BMC Neurology, August 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)

Mentioned by

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4 tweeters
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1 Facebook page

Citations

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9 Dimensions

Readers on

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21 Mendeley
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Title
Partial loss of VE-cadherin improves long-term outcome and cerebral blood flow after transient brain ischemia in mice
Published in
BMC Neurology, August 2016
DOI 10.1186/s12883-016-0670-8
Pubmed ID
Authors

Karen Gertz, Golo Kronenberg, Ria Uhlemann, Vincent Prinz, Ruben Marquina, Monica Corada, Elisabetta Dejana, Matthias Endres

Abstract

VE-cadherin is the chief constituent of endothelial adherens junctions. However, the role of VE-cadherin in the pathogenesis of cerebrovascular diseases including brain ischemia has not yet been investigated. VE-cadherin heterozygous (VEC(+/-)) mice and wildtype controls were subjected to transient brain ischemia by 30 min filamentous middle cerebral artery occlusion (MCAo)/reperfusion. Acute lesion sizes as assessed by MR-imaging on day 3 did not differ between genotypes. Unexpectedly, however, partial loss of VE-cadherin resulted in long-term stroke protection measured histologically on day 28. Equally surprisingly, VEC(+/-) mice displayed no differences in post-stroke angiogenesis compared to littermate controls, but showed increased absolute regional cerebral blood flow in ischemic striatum at four weeks. The early induction of VE-cadherin mRNA transcription after stroke was reduced in VEC(+/-) mice. By contrast, N-cadherin and β-catenin mRNA expression showed a delayed, but sustained, upregulation up to 28 days after MCAo, which was increased in VEC(+/-) mice. Furthermore, partial loss of VE-cadherin resulted in a pattern of elevated ischemia-triggered mRNA transcription of pericyte-related molecules α-smooth muscle actin (α-SMA), aminopeptidase N (CD13), and platelet-derived growth factor receptor β (PDGFR-β). Partial loss of VE-cadherin results in long term stroke protection. On the cellular and molecular level, this effect appears to be mediated by improved endothelial/pericyte interactions and the resultant increase in cerebral blood flow. Our study reinforces accumulating evidence that long-term stroke outcome depends critically on vascular mechanisms.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 29%
Student > Master 3 14%
Other 2 10%
Student > Doctoral Student 1 5%
Lecturer 1 5%
Other 5 24%
Unknown 3 14%
Readers by discipline Count As %
Neuroscience 5 24%
Agricultural and Biological Sciences 4 19%
Medicine and Dentistry 3 14%
Biochemistry, Genetics and Molecular Biology 2 10%
Immunology and Microbiology 1 5%
Other 2 10%
Unknown 4 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2016.
All research outputs
#8,398,924
of 15,918,484 outputs
Outputs from BMC Neurology
#683
of 1,793 outputs
Outputs of similar age
#107,788
of 267,743 outputs
Outputs of similar age from BMC Neurology
#1
of 1 outputs
Altmetric has tracked 15,918,484 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,793 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them