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Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study

Overview of attention for article published in Cancer Communications, August 2016
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Title
Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study
Published in
Cancer Communications, August 2016
DOI 10.1186/s40880-016-0136-9
Pubmed ID
Authors

Limin Miao, Lihua Wang, Longbiao Zhu, Jiangbo Du, Xun Zhu, Yuming Niu, Ruixia Wang, Zhibin Hu, Ning Chen, Hongbing Shen, Hongxia Ma

Abstract

MicroRNA (miRNA) polymorphisms may alter miRNA-related processes, and they likely contribute to cancer susceptibility. Various studies have investigated the associations between genetic variants in several key miRNAs and the risk of human cancers; however, few studies have focused on head and neck squamous cell carcinoma (HNSCC) risk. This study aimed to evaluate the associations between several key miRNA polymorphisms and HNSCC risk in a Chinese population. In this study, we genotyped five common single-nucleotide polymorphisms (SNPs) in several key miRNAs (miR-149 rs2292832, miR-146a rs2910164, miR-605 rs2043556, miR-608 rs4919510, and miR-196a2 rs11614913) and evaluated the associations between these SNPs and HNSCC risk according to cancer site with a case-control study including 576 cases and 1552 controls, which were matched by age and sex in a Chinese population. The results revealed that miR-605 rs2043556 [dominant model: adjusted odds ratio (OR) 0.71, 95% confidence interval (CI) 0.58-0.88; additive model: adjusted OR 0.74, 95% CI 0.62-0.89] and miR-196a2 rs11614913 (dominant model: adjusted OR 1.36, 95% CI 1.08-1.72; additive model: adjusted OR 1.28, 95% CI 1.10-1.48) were significantly associated with the risk of oral squamous cell carcinoma (OSCC). Furthermore, when these two loci were evaluated together based on the number of putative risk alleles (rs2043556 A and rs11614913 G), a significant locus-dosage effect was noted on the risk of OSCC (P trend < 0.001). However, no significant association was detected between the other three SNPs (miR-149 rs2292832, miR-146a rs2910164, and miR-608 rs4919510) and HNSCC risk. Our study provided the evidence that miR-605 rs2043556 and miR-196a2 rs11614913 may have an impact on genetic susceptibility to OSCC in Chinese population.

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The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 4 17%
Student > Ph. D. Student 3 13%
Researcher 3 13%
Student > Master 3 13%
Other 2 9%
Other 3 13%
Unknown 5 22%
Readers by discipline Count As %
Medicine and Dentistry 9 39%
Biochemistry, Genetics and Molecular Biology 7 30%
Immunology and Microbiology 1 4%
Agricultural and Biological Sciences 1 4%
Unknown 5 22%