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Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1

Overview of attention for article published in BMC Infectious Diseases, November 2012
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Title
Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1
Published in
BMC Infectious Diseases, November 2012
DOI 10.1186/1471-2334-12-314
Pubmed ID
Authors

Hussin A Rothan, Heh Choon Han, Thamil Selvee Ramasamy, Shatrah Othman, Noorsaadah Abd Rahman, Rohana Yusof

Abstract

Global resurgence of dengue virus infections in many of the tropical and subtropical countries is a major concern. Therefore, there is an urgent need for the development of successful drugs that are both economical and offer a long-lasting protection. The viral NS2B-NS3 serine protease (NS2B-NS3pro) is a promising target for the development of drug-like inhibitors, which are not available at the moment. In this study, we report retrocyclin-1 (RC-1) production in E. coli as a recombinant peptide to test against dengue NS2B-NS3pro.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 126 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 17%
Student > Bachelor 20 16%
Student > Master 15 12%
Researcher 11 9%
Student > Doctoral Student 6 5%
Other 24 19%
Unknown 29 23%
Readers by discipline Count As %
Chemistry 22 17%
Agricultural and Biological Sciences 18 14%
Biochemistry, Genetics and Molecular Biology 16 13%
Immunology and Microbiology 13 10%
Medicine and Dentistry 10 8%
Other 15 12%
Unknown 33 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2012.
All research outputs
#20,174,175
of 22,687,320 outputs
Outputs from BMC Infectious Diseases
#6,425
of 7,643 outputs
Outputs of similar age
#244,639
of 275,937 outputs
Outputs of similar age from BMC Infectious Diseases
#114
of 146 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,643 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,937 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 146 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.