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Rapid evolutionary adaptation to growth on an ‘unfamiliar’ carbon source

Overview of attention for article published in BMC Genomics, August 2016
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Title
Rapid evolutionary adaptation to growth on an ‘unfamiliar’ carbon source
Published in
BMC Genomics, August 2016
DOI 10.1186/s12864-016-3010-x
Pubmed ID
Authors

Zvi Tamari, Avihu H. Yona, Yitzhak Pilpel, Naama Barkai

Abstract

Cells constantly adapt to changes in their environment. When environment shifts between conditions that were previously encountered during the course of evolution, evolutionary-programmed responses are possible. Cells, however, may also encounter a new environment to which a novel response is required. To characterize the first steps in adaptation to a novel condition, we studied budding yeast growth on xylulose, a sugar that is very rarely found in the wild. We previously reported that growth on xylulose induces the expression of amino acid biosynthesis genes in multiple natural yeast isolates. This induction occurs despite the presence of amino acids in the growth medium and is a unique response to xylulose, not triggered by naturally available carbon sources. Propagating these strains for ~300 generations on xylulose significantly improved their growth rate. Notably, the most significant change in gene expression was the loss of amino acid biosynthesis gene induction. Furthermore, the reduction in amino-acid biosynthesis gene expression on xylulose was tightly correlated with the improvement in growth rate, suggesting that internal depletion of amino-acids presented a major bottleneck limiting growth in xylulose. We discuss the possible implications of our results for explaining how cells maintain the balance between supply and demand of amino acids during growth in evolutionary 'familiar' vs. 'novel' conditions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Thailand 1 3%
Unknown 34 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 28%
Researcher 9 25%
Student > Bachelor 4 11%
Student > Master 2 6%
Student > Doctoral Student 1 3%
Other 4 11%
Unknown 6 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 42%
Biochemistry, Genetics and Molecular Biology 10 28%
Environmental Science 1 3%
Physics and Astronomy 1 3%
Social Sciences 1 3%
Other 2 6%
Unknown 6 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2016.
All research outputs
#15,381,416
of 22,883,326 outputs
Outputs from BMC Genomics
#6,701
of 10,668 outputs
Outputs of similar age
#217,914
of 341,481 outputs
Outputs of similar age from BMC Genomics
#169
of 273 outputs
Altmetric has tracked 22,883,326 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,668 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,481 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 273 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.