Title |
MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
|
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Published in |
Radiation Oncology, November 2012
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DOI | 10.1186/1748-717x-7-195 |
Pubmed ID | |
Authors |
Marek Svoboda, Jiri Sana, Pavel Fabian, Ilona Kocakova, Jana Gombosova, Jana Nekvindova, Lenka Radova, Rostislav Vyzula, Ondrej Slaby |
Abstract |
Rectal cancer accounts for approximately one third of all colorectal cancers (CRC), which belong among leading causes of cancer deaths worldwide. Standard treatment for locally advanced rectal cancer (cT3/4 and/or cN+) includes neoadjuvant chemoradiotherapy with fluoropyrimidines (capecitabine or 5-fluorouracil) followed by radical surgical resection. Unfortunately, a significant proportion of tumors do not respond enough to the neoadjuvant treatment and these patients are at risk of relapse. MicroRNAs (miRNAs) are small non-coding RNAs playing significant roles in the pathogenesis of many cancers including rectal cancer. MiRNAs could present the new predictive biomarkers for rectal cancer patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 1% |
Unknown | 71 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 22% |
Researcher | 13 | 18% |
Student > Master | 13 | 18% |
Student > Bachelor | 8 | 11% |
Other | 6 | 8% |
Other | 8 | 11% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 39% |
Biochemistry, Genetics and Molecular Biology | 17 | 24% |
Agricultural and Biological Sciences | 10 | 14% |
Nursing and Health Professions | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
Other | 4 | 6% |
Unknown | 10 | 14% |