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MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

Overview of attention for article published in Radiation Oncology, November 2012
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1 tweeter
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1 Facebook page

Citations

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106 Dimensions

Readers on

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66 Mendeley

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Title
MicroRNA expression profile associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients
Published in
Radiation Oncology, November 2012
DOI 10.1186/1748-717x-7-195
Pubmed ID
23167930
Authors

Marek Svoboda, Jiri Sana, Pavel Fabian, Ilona Kocakova, Jana Gombosova, Jana Nekvindova, Lenka Radova, Rostislav Vyzula, Ondrej Slaby

Abstract

Rectal cancer accounts for approximately one third of all colorectal cancers (CRC), which belong among leading causes of cancer deaths worldwide. Standard treatment for locally advanced rectal cancer (cT3/4 and/or cN+) includes neoadjuvant chemoradiotherapy with fluoropyrimidines (capecitabine or 5-fluorouracil) followed by radical surgical resection. Unfortunately, a significant proportion of tumors do not respond enough to the neoadjuvant treatment and these patients are at risk of relapse. MicroRNAs (miRNAs) are small non-coding RNAs playing significant roles in the pathogenesis of many cancers including rectal cancer. MiRNAs could present the new predictive biomarkers for rectal cancer patients.

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Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Spain 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 26%
Researcher 13 20%
Student > Master 13 20%
Student > Bachelor 6 9%
Other 5 8%
Other 6 9%
Unknown 6 9%
Readers by discipline Count As %
Medicine and Dentistry 28 42%
Biochemistry, Genetics and Molecular Biology 15 23%
Agricultural and Biological Sciences 10 15%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Environmental Science 1 2%
Other 3 5%
Unknown 8 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2012.
All research outputs
#9,555,954
of 12,437,730 outputs
Outputs from Radiation Oncology
#875
of 1,302 outputs
Outputs of similar age
#171,074
of 258,129 outputs
Outputs of similar age from Radiation Oncology
#103
of 137 outputs
Altmetric has tracked 12,437,730 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,302 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,129 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 137 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.

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