Title |
Nucleophosmin: from structure and function to disease development
|
---|---|
Published in |
BMC Molecular and Cell Biology, August 2016
|
DOI | 10.1186/s12867-016-0073-9 |
Pubmed ID | |
Authors |
Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne, Derek J. Richard |
Abstract |
Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Venezuela, Bolivarian Republic of | 1 | 50% |
France | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
Unknown | 318 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 50 | 16% |
Student > Bachelor | 50 | 16% |
Student > Master | 40 | 13% |
Researcher | 37 | 12% |
Student > Doctoral Student | 16 | 5% |
Other | 37 | 12% |
Unknown | 89 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 121 | 38% |
Agricultural and Biological Sciences | 44 | 14% |
Medicine and Dentistry | 26 | 8% |
Chemistry | 8 | 3% |
Immunology and Microbiology | 6 | 2% |
Other | 18 | 6% |
Unknown | 96 | 30% |