Title |
Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis
|
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Published in |
BMC Neurology, November 2012
|
DOI | 10.1186/1471-2377-12-140 |
Pubmed ID | |
Authors |
Kota Bokuda, Keizo Sugaya, Shunichiro Tamura, Kazuhito Miyamoto, Shiro Matsubara, Takashi Komori |
Abstract |
The autophagic vacuolar myopathies (AVM) are a group of inherited myopathies defined by the presence of autophagic vacuoles in pathological muscle specimens. AVM can be categorized into three groups: acid maltase deficiency, myopathies characterized by autophagic vacuoles with unique sarcolemmal features, and rimmed vacuolar myopathies (RVM). While the pathogeneses of these conditions are still being elucidated, some drugs (e.g., chloroquine, its analog, hydroxychloroquine, and colchicine) can also cause AVM. Minocycline is a disease-modifying anti-rheumatic drug that may be used in the treatment of rheumatoid arthritis (RA). Here, we describe the first case of minocycline-associated AVM with rimmed vacuole formation. |
X Demographics
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United States | 1 | 50% |
Demographic breakdown
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Singapore | 1 | 4% |
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Demographic breakdown
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Student > Master | 3 | 11% |
Other | 2 | 7% |
Professor > Associate Professor | 2 | 7% |
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