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IL-12 based gene therapy in veterinary medicine

Overview of attention for article published in Journal of Translational Medicine, November 2012
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  • Above-average Attention Score compared to outputs of the same age and source (56th percentile)

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3 X users

Citations

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38 Dimensions

Readers on

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96 Mendeley
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Title
IL-12 based gene therapy in veterinary medicine
Published in
Journal of Translational Medicine, November 2012
DOI 10.1186/1479-5876-10-234
Pubmed ID
Authors

Darja Pavlin, Maja Cemazar, Gregor Sersa, Natasa Tozon

Abstract

The use of large animals as an experimental model for novel treatment techniques has many advantages over the use of laboratory animals, so veterinary medicine is becoming an increasingly important translational bridge between preclinical studies and human medicine. The results of preclinical studies show that gene therapy with therapeutic gene encoding interleukin-12 (IL-12) displays pronounced antitumor effects in various tumor models. A number of different studies employing this therapeutic plasmid, delivered by either viral or non-viral methods, have also been undertaken in veterinary oncology. In cats, adenoviral delivery into soft tissue sarcomas has been employed. In horses, naked plasmid DNA has been delivered by direct intratumoral injection into nodules of metastatic melanoma. In dogs, various types of tumors have been treated with either local or systemic IL-12 electrogene therapy. The results of these studies show that IL-12 based gene therapy elicits a good antitumor effect on spontaneously occurring tumors in large animals, while being safe and well tolerated by the animals. Hopefully, such results will lead to further investigation of this therapy in veterinary medicine and successful translation into human clinical trials.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 1%
Italy 1 1%
Unknown 94 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 18%
Student > Ph. D. Student 14 15%
Student > Master 12 13%
Student > Bachelor 9 9%
Student > Postgraduate 7 7%
Other 19 20%
Unknown 18 19%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 19 20%
Biochemistry, Genetics and Molecular Biology 15 16%
Medicine and Dentistry 15 16%
Agricultural and Biological Sciences 12 13%
Immunology and Microbiology 5 5%
Other 15 16%
Unknown 15 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 December 2012.
All research outputs
#13,372,313
of 22,687,320 outputs
Outputs from Journal of Translational Medicine
#1,575
of 3,963 outputs
Outputs of similar age
#155,803
of 275,937 outputs
Outputs of similar age from Journal of Translational Medicine
#38
of 92 outputs
Altmetric has tracked 22,687,320 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,963 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.5. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,937 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 92 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.