Title |
Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders
|
---|---|
Published in |
Skeletal Muscle, November 2011
|
DOI | 10.1186/2044-5040-1-34 |
Pubmed ID | |
Authors |
Kamel Mamchaoui, Capucine Trollet, Anne Bigot, Elisa Negroni, Soraya Chaouch, Annie Wolff, Prashanth K Kandalla, Solenne Marie, James Di Santo, Jean Lacau St Guily, Francesco Muntoni, Jihee Kim, Susanne Philippi, Simone Spuler, Nicolas Levy, Sergiu C Blumen, Thomas Voit, Woodring E Wright, Ahmed Aamiri, Gillian Butler-Browne, Vincent Mouly |
Abstract |
Investigations into both the pathophysiology and therapeutic targets in muscle dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Isolation of reliable and stable immortalized cell lines from patient biopsies is a powerful tool for investigating pathological mechanisms, including those associated with muscle aging, and for developing innovative gene-based, cell-based or pharmacological biotherapies. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 3 | <1% |
United States | 2 | <1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Japan | 1 | <1% |
Belgium | 1 | <1% |
Unknown | 308 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 74 | 23% |
Student > Ph. D. Student | 65 | 21% |
Student > Master | 38 | 12% |
Student > Bachelor | 20 | 6% |
Professor > Associate Professor | 13 | 4% |
Other | 45 | 14% |
Unknown | 62 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 93 | 29% |
Agricultural and Biological Sciences | 73 | 23% |
Medicine and Dentistry | 23 | 7% |
Engineering | 12 | 4% |
Neuroscience | 11 | 3% |
Other | 33 | 10% |
Unknown | 72 | 23% |