Title |
Experimental determination of the oral bioavailability and bioaccessibility of lead particles
|
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Published in |
BMC Chemistry, November 2012
|
DOI | 10.1186/1752-153x-6-138 |
Pubmed ID | |
Authors |
Elise Deshommes, Robert Tardif, Marc Edwards, Sébastien Sauvé, Michèle Prévost |
Abstract |
In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Germany | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Spain | 1 | 1% |
Unknown | 93 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 17 | 18% |
Student > Bachelor | 16 | 17% |
Researcher | 13 | 14% |
Student > Ph. D. Student | 11 | 12% |
Student > Doctoral Student | 6 | 6% |
Other | 14 | 15% |
Unknown | 17 | 18% |
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Agricultural and Biological Sciences | 11 | 12% |
Engineering | 6 | 6% |
Chemistry | 5 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 13 | 14% |
Unknown | 27 | 29% |