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Experimental determination of the oral bioavailability and bioaccessibility of lead particles

Overview of attention for article published in BMC Chemistry, November 2012
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Title
Experimental determination of the oral bioavailability and bioaccessibility of lead particles
Published in
BMC Chemistry, November 2012
DOI 10.1186/1752-153x-6-138
Pubmed ID
Authors

Elise Deshommes, Robert Tardif, Marc Edwards, Sébastien Sauvé, Michèle Prévost

Abstract

In vivo estimations of Pb particle bioavailability are costly and variable, because of the nature of animal assays. The most feasible alternative for increasing the number of investigations carried out on Pb particle bioavailability is in vitro testing. This testing method requires calibration using in vivo data on an adapted animal model, so that the results will be valid for childhood exposure assessment. Also, the test results must be reproducible within and between laboratories. The Relative Bioaccessibility Leaching Procedure, which is calibrated with in vivo data on soils, presents the highest degree of validation and simplicity. This method could be applied to Pb particles, including those in paint and dust, and those in drinking water systems, which although relevant, have been poorly investigated up to now for childhood exposure assessment.

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Mendeley readers

The data shown below were compiled from readership statistics for 94 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
Unknown 93 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 18%
Student > Bachelor 16 17%
Researcher 13 14%
Student > Ph. D. Student 11 12%
Student > Doctoral Student 6 6%
Other 14 15%
Unknown 17 18%
Readers by discipline Count As %
Environmental Science 28 30%
Agricultural and Biological Sciences 11 12%
Engineering 6 6%
Chemistry 5 5%
Pharmacology, Toxicology and Pharmaceutical Science 4 4%
Other 13 14%
Unknown 27 29%