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Influence of changes in serum uric acid levels on renal function in elderly patients with hypertension: a retrospective cohort study with 3.5-year follow-up

Overview of attention for article published in BMC Geriatrics, February 2016
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2 tweeters

Citations

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9 Dimensions

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30 Mendeley
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Title
Influence of changes in serum uric acid levels on renal function in elderly patients with hypertension: a retrospective cohort study with 3.5-year follow-up
Published in
BMC Geriatrics, February 2016
DOI 10.1186/s12877-016-0209-2
Pubmed ID
Authors

Fan Lin, Hailin Zhang, Feng Huang, Hui Chen, Chunjin Lin, Pengli Zhu

Abstract

Hyperuricemia is closely related to renal diseases. Therefore, the aim of this study was to explore the relationship between the longitudinal changes in serum uric acid and the estimated glomerular filtration rate (eGFR) in a cohort of elderly hypertensive patients. Eighty hundred and thirty-seven re-hospitalized patients with hypertension were included in this retrospective cohort study. Multiple regression analysis was used to investigate the relationship between changes in serum uric acid and renal function after 3.5 years follow-up. The average age at baseline was 69.0+/-10.0 years, and the average follow-up duration was 3.5 years. Multiple linear regression analysis showed that the baseline uric acid levels had a linearly negative correlation with baseline eGFR (P < 0.01), after adjustment for age, gender, blood pressure, and body mass index, et al. An increase of 100 μmol/L baseline uric acid level resulted in a decrease of 5.684 ml/min/1.73 m(2) in eGFR [95 % confidence interval (CI): 7.735-3.633]. Patients with increased uric acid levels had higher risk of renal function decline over the follow-up period, with an adjusted odds ratio of 1.639 (95 % CI: 1.129-2.378, P = 0.009) , whereas eGFR was remained unchanged in patients with hyperuricemia at baseline and with normal uric acid level 3.5-year later. Longitudinal changes in uric acid levels were independently associated with the renal function decline in elderly patients with hypertension. Uric acid level should be considered in hypertension management in the elderly.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Belgium 1 3%
Unknown 28 93%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 23%
Student > Master 5 17%
Student > Doctoral Student 4 13%
Researcher 2 7%
Student > Postgraduate 2 7%
Other 6 20%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 15 50%
Nursing and Health Professions 5 17%
Arts and Humanities 1 3%
Unspecified 1 3%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 2 7%
Unknown 5 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 August 2016.
All research outputs
#8,286,104
of 13,219,992 outputs
Outputs from BMC Geriatrics
#1,086
of 1,370 outputs
Outputs of similar age
#144,301
of 261,583 outputs
Outputs of similar age from BMC Geriatrics
#1
of 1 outputs
Altmetric has tracked 13,219,992 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,370 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.4. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,583 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them