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Epstein-Barr viral microRNAs target caspase 3

Overview of attention for article published in Virology Journal, August 2016
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3 tweeters

Citations

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21 Dimensions

Readers on

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36 Mendeley
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Title
Epstein-Barr viral microRNAs target caspase 3
Published in
Virology Journal, August 2016
DOI 10.1186/s12985-016-0602-7
Pubmed ID
Authors

Cecelia Harold, Diana Cox, Kasandra J. Riley

Abstract

The Epstein-Barr virus (EBV) is a ubiquitous herpesvirus that transforms B cells and causes several malignancies including Burkitt's lymphoma. EBV differentially expresses at least 49 mature microRNAs (miRNAs) during latency in various infected epithelial and B cells. Recent high-throughput studies and functional assays have begun to reveal the function of the EBV miRNAs suggesting roles in latency, cell cycle control, and apoptosis. In particular, the central executioner of apoptosis, Caspase 3 (CASP3), was proposed as a target of select EBV miRNAs. However, whether CASP3 is truly a target of EBV miRNAs, and if so, which specific miRNAs target CASP3 is still under debate. Based on previously published high-throughput biochemical data and a bioinformatic analysis of the entire CASP3 3'-UTR, we identified 12 EBV miRNAs that have one or more seed binding sites in the CASP3 3'-UTR. We individually tested all 12 miRNAs for repression of CASP3 in luciferase reporter assays, and nine showed statistically significant (P < 0.001) repression of a full-length CASP3 reporter. Further, three EBV miRNAs, including BART22, exhibited repression of endogenous CASP3 protein. These data confirm that CASP3 is a direct target of specific EBV BART miRNAs.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 19%
Other 5 14%
Student > Master 5 14%
Student > Ph. D. Student 4 11%
Researcher 4 11%
Other 6 17%
Unknown 5 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 22%
Biochemistry, Genetics and Molecular Biology 8 22%
Immunology and Microbiology 4 11%
Medicine and Dentistry 3 8%
Chemical Engineering 2 6%
Other 7 19%
Unknown 4 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2016.
All research outputs
#4,192,947
of 8,324,953 outputs
Outputs from Virology Journal
#929
of 1,679 outputs
Outputs of similar age
#128,029
of 252,536 outputs
Outputs of similar age from Virology Journal
#23
of 40 outputs
Altmetric has tracked 8,324,953 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,679 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,536 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.